Iron stores and obesity are negatively associated with ovarian volume and anti-Müllerian hormone levels in women with polycystic ovary syndrome

Abstract Objective Obesity and insulin resistance are associated with increased iron stores, but have conflicting effects on ovarian reserve in women with polycystic ovary syndrome (PCOS). Iron-catalyzed oxidative stress might be detrimental to ovarian tissue and granulosa cell function. In this stu...

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Published in:Taiwanese journal of obstetrics & gynecology 2015-12, Vol.54 (6), p.686-692
Main Authors: Yang, Jehn-Hsiahn, Chou, Chia-Hung, Yang, Wei-Shiung, Ho, Hong-Nerng, Yang, Yu-Shih, Chen, Mei-Jou
Format: Article
Language:English
Subjects:
anti-Müllerian hormone
ferritin
Internal Medicine
iron stores
obesity
Obstetrics and Gynecology
ovarian volume
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Summary:Abstract Objective Obesity and insulin resistance are associated with increased iron stores, but have conflicting effects on ovarian reserve in women with polycystic ovary syndrome (PCOS). Iron-catalyzed oxidative stress might be detrimental to ovarian tissue and granulosa cell function. In this study we determined the association between body iron stores, obesity, and ovarian reserve in women with PCOS. Materials and Methods One hundred and fifty-six women diagnosed with PCOS according to Rotterdam criteria and 30 normoweight healthy control women were enrolled in this cross-sectional study. Ovarian volume, total antral follicle count, and the anti-Müllerian hormone (AMH) level were measured as an indicator of ovarian reserve. Results Ferritin and transferrin-bound iron levels were significantly higher in women with PCOS than normoweight controls. Obese women with PCOS had higher ferritin levels ( p  = 0.006), but lower AMH levels ( p  
ISSN:1028-4559
DOI:10.1016/j.tjog.2014.11.025