TLR3, TLR7, and TLR8 genes expression datasets in COVID-19 patients: Influences of the disease severity and gender

• Published in: Data in brief 2024-06, Vol.54, p.110498, Article 110498
• Main Authors: Arefinia, Nasir, Banafi, Parsa, Zarezadeh, Mohammad Amin, Mousawi, Hawra Shah, Yaghobi, Ramin, Farokhnia, Mehrdad, Sarvari, Jamal
• Format: Article
• Language: English
• Subjects: Coronavirus disease 2019; Data; Severe acute respiratory syndrome coronavirus 2; TLR7; TLR8; Toll-like receptors 3 (TLR3)
• ISSN: 2352-3409; 2352-3409
• DOI: 10.1016/j.dib.2024.110498

The prognosis of COVID-19 could influence by innate immune sensors such as toll-like receptors (TLRs). The purpose of this data was to investigate TLR3, 7, and 8 expression levels in COVID-19 patients and their relationship to outcome of disease. 75 confirm COVID-19 were included sequentially and separated into three groups: mild, severe, and critical. Peripheral blood mononuclear cells were isolated from the whole blood, and RNA was then extracted. The qRT-PCR technique was used to examine the expression of TLR3, TLR7, and TLR8 genes. The patients average ages were 52.69 ± 1.9 and 13 of the 25 individuals in each group were male. TLR3 (p < 0.001), TLR7 (p < 0.001), and TLR8 (p < 0.001) expression levels were considerably greater in COVID-19 patients compared to the control group. The findings also showed that individuals with critical and severe COVID-19 disease had significantly greater TLR7 and TLR8 gene expression levels than patients in mild stage of disease (p < 0.05). The data showed a significant difference (p = 0.01) in the TLR3 transcript levels between critical and mild COVID-19 patients. Furthermore, male severe (p = 0.02) and critical (p = 0.008) patients had significantly higher TLR8 expression levels than female patients in terms of gender. TLR3 (p = 0.2) and TLR7 (p = 0.08) transcripts were more elevated in males than females, but not significantly.