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Acute exercise in mice transiently remodels the hepatic lipidome in an intensity-dependent manner
Background The content of triacylglycerol (TAG) in the liver is known to rapidly increase after a single bout of exercise followed by recovery to sedentary levels. The response of other hepatic lipids, and acyl chain composition of lipid classes, would provide a deeper understanding of the response...
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Published in: | Lipids in health and disease 2020-10, Vol.19 (1), p.1-219, Article 219 |
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description | Background The content of triacylglycerol (TAG) in the liver is known to rapidly increase after a single bout of exercise followed by recovery to sedentary levels. The response of other hepatic lipids, and acyl chain composition of lipid classes, would provide a deeper understanding of the response of hepatic lipid metabolism to acute exercise. Methods Female mice performed a single bout of continuous exercise (CE), high-intensity interval exercise (HIIE), or no exercise (CON). The total content of various lipids in the liver, and fatty acids within lipid classes, were measured in tissues collected 3 h after exercise (Day 1) and the day following exercise (Day 2). Results The total concentration of TAG rose on Day 1 after exercise (P < 0.05), with a greater elevation in HIIE than CE (P < 0.05), followed by a decline toward CON levels on Day 2. The total concentration of other measured lipid classes was not significantly altered by exercise. However, n-6 polyunsaturated fatty acid relative abundance in diacylglycerol (DAG) was increased by HIIE (P < 0.05). In CON liver, TAG content was positively correlated with DAG and phosphatidylethanolamine (P < 0.05), while these statistical associations were disrupted in exercised mice on Day 1. Conclusions The response of lipid metabolism to exercise involves the coordination of metabolism between various tissues, and the lipid metabolism response to acute exercise places a metabolic burden upon the liver. The present findings describe how the liver copes with this metabolic challenge. The flexibility of the TAG pool size in the liver, and other remodeling of the hepatic lipidome, may be fundamental components of the physiological response to intense exercise. Keywords: Lipidomics, High-intensity interval training, Postexercise recovery, Post-exercise, Intrahepatocellular lipid, Triglyceride |
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The response of other hepatic lipids, and acyl chain composition of lipid classes, would provide a deeper understanding of the response of hepatic lipid metabolism to acute exercise. Methods Female mice performed a single bout of continuous exercise (CE), high-intensity interval exercise (HIIE), or no exercise (CON). The total content of various lipids in the liver, and fatty acids within lipid classes, were measured in tissues collected 3 h after exercise (Day 1) and the day following exercise (Day 2). Results The total concentration of TAG rose on Day 1 after exercise (P < 0.05), with a greater elevation in HIIE than CE (P < 0.05), followed by a decline toward CON levels on Day 2. The total concentration of other measured lipid classes was not significantly altered by exercise. However, n-6 polyunsaturated fatty acid relative abundance in diacylglycerol (DAG) was increased by HIIE (P < 0.05). In CON liver, TAG content was positively correlated with DAG and phosphatidylethanolamine (P < 0.05), while these statistical associations were disrupted in exercised mice on Day 1. Conclusions The response of lipid metabolism to exercise involves the coordination of metabolism between various tissues, and the lipid metabolism response to acute exercise places a metabolic burden upon the liver. The present findings describe how the liver copes with this metabolic challenge. The flexibility of the TAG pool size in the liver, and other remodeling of the hepatic lipidome, may be fundamental components of the physiological response to intense exercise. Keywords: Lipidomics, High-intensity interval training, Postexercise recovery, Post-exercise, Intrahepatocellular lipid, Triglyceride</description><identifier>ISSN: 1476-511X</identifier><identifier>EISSN: 1476-511X</identifier><identifier>DOI: 10.1186/s12944-020-01395-4</identifier><identifier>PMID: 33032600</identifier><language>eng</language><publisher>London: BioMed Central Ltd</publisher><subject>Diglycerides ; Fatty acids ; Fitness equipment ; Fitness training programs ; High-intensity interval training ; Human subjects ; Intrahepatocellular lipid ; Laboratory animals ; Lipid metabolism ; Lipidomics ; Lipids ; Liver ; Metabolism ; Musculoskeletal system ; Phosphatidylethanolamine ; Physiological aspects ; Polyunsaturated fatty acids ; Post-exercise ; Postexercise recovery ; Running ; Triglyceride</subject><ispartof>Lipids in health and disease, 2020-10, Vol.19 (1), p.1-219, Article 219</ispartof><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-7b04199a26157466135810f7d64fdca128dd4e733483f9807cf4bb4aa7ab43133</citedby><cites>FETCH-LOGICAL-c540t-7b04199a26157466135810f7d64fdca128dd4e733483f9807cf4bb4aa7ab43133</cites><orcidid>0000-0003-3505-9953</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545884/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2451931330?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,25734,27905,27906,36993,36994,44571,53772,53774</link.rule.ids></links><search><creatorcontrib>Henderson, Gregory C.</creatorcontrib><creatorcontrib>Martinez Tenorio, Valeria</creatorcontrib><creatorcontrib>Tuazon, Marc A.</creatorcontrib><title>Acute exercise in mice transiently remodels the hepatic lipidome in an intensity-dependent manner</title><title>Lipids in health and disease</title><description>Background The content of triacylglycerol (TAG) in the liver is known to rapidly increase after a single bout of exercise followed by recovery to sedentary levels. The response of other hepatic lipids, and acyl chain composition of lipid classes, would provide a deeper understanding of the response of hepatic lipid metabolism to acute exercise. Methods Female mice performed a single bout of continuous exercise (CE), high-intensity interval exercise (HIIE), or no exercise (CON). The total content of various lipids in the liver, and fatty acids within lipid classes, were measured in tissues collected 3 h after exercise (Day 1) and the day following exercise (Day 2). Results The total concentration of TAG rose on Day 1 after exercise (P < 0.05), with a greater elevation in HIIE than CE (P < 0.05), followed by a decline toward CON levels on Day 2. The total concentration of other measured lipid classes was not significantly altered by exercise. However, n-6 polyunsaturated fatty acid relative abundance in diacylglycerol (DAG) was increased by HIIE (P < 0.05). In CON liver, TAG content was positively correlated with DAG and phosphatidylethanolamine (P < 0.05), while these statistical associations were disrupted in exercised mice on Day 1. Conclusions The response of lipid metabolism to exercise involves the coordination of metabolism between various tissues, and the lipid metabolism response to acute exercise places a metabolic burden upon the liver. The present findings describe how the liver copes with this metabolic challenge. The flexibility of the TAG pool size in the liver, and other remodeling of the hepatic lipidome, may be fundamental components of the physiological response to intense exercise. Keywords: Lipidomics, High-intensity interval training, Postexercise recovery, Post-exercise, Intrahepatocellular lipid, Triglyceride</description><subject>Diglycerides</subject><subject>Fatty acids</subject><subject>Fitness equipment</subject><subject>Fitness training programs</subject><subject>High-intensity interval training</subject><subject>Human subjects</subject><subject>Intrahepatocellular lipid</subject><subject>Laboratory animals</subject><subject>Lipid metabolism</subject><subject>Lipidomics</subject><subject>Lipids</subject><subject>Liver</subject><subject>Metabolism</subject><subject>Musculoskeletal system</subject><subject>Phosphatidylethanolamine</subject><subject>Physiological aspects</subject><subject>Polyunsaturated fatty acids</subject><subject>Post-exercise</subject><subject>Postexercise recovery</subject><subject>Running</subject><subject>Triglyceride</subject><issn>1476-511X</issn><issn>1476-511X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptUk2PFCEU7BiNu67-AU-dePHSKx8PaC4mk40fm2ziRRNvhIbXM0y6YYQes_PvZWY26hoDAfKoKiiopnlNyTWlvXxXKNMAHWGkI5Rr0cGT5pKCkp2g9PvTv9YXzYtStqQilZTPmwvOCWeSkMvGrtx-wRbvMbtQsA2xnYPDdsk2loBxmQ5txjl5nEq7bLDd4M4uwbVT2AWf5hPDxjouWAnLofO4w-grs51tjJhfNs9GOxV89TBfNd8-fvh687m7-_Lp9mZ11zkBZOnUQIBqbZmkQoGUlIueklF5CaN3lrLee0DFOfR81D1RboRhAGuVHYBTzq-a27OuT3ZrdjnMNh9MssGcCimvjc315hMay5hSIx0JCAJOEu0BgDGqBk2E9rpqvT9r7fbDjN5VN9lOj0Qf78SwMev00ygBou-hCrx9EMjpxx7LYuZQHE6TjZj2xTAArQWAPELf_APdpn2O9akqSlB99Eb-oNa2GghxTPVcdxQ1K8l7kLXLirr-D6o2j_VXU8Qx1PojAjsTXE6lZBx_e6TEHENmziEzNTrmFDID_BdoQsE6</recordid><startdate>20201008</startdate><enddate>20201008</enddate><creator>Henderson, Gregory C.</creator><creator>Martinez Tenorio, Valeria</creator><creator>Tuazon, Marc A.</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3505-9953</orcidid></search><sort><creationdate>20201008</creationdate><title>Acute exercise in mice transiently remodels the hepatic lipidome in an intensity-dependent manner</title><author>Henderson, Gregory C. ; Martinez Tenorio, Valeria ; Tuazon, Marc A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-7b04199a26157466135810f7d64fdca128dd4e733483f9807cf4bb4aa7ab43133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Diglycerides</topic><topic>Fatty acids</topic><topic>Fitness equipment</topic><topic>Fitness training programs</topic><topic>High-intensity interval training</topic><topic>Human subjects</topic><topic>Intrahepatocellular lipid</topic><topic>Laboratory animals</topic><topic>Lipid metabolism</topic><topic>Lipidomics</topic><topic>Lipids</topic><topic>Liver</topic><topic>Metabolism</topic><topic>Musculoskeletal system</topic><topic>Phosphatidylethanolamine</topic><topic>Physiological aspects</topic><topic>Polyunsaturated fatty acids</topic><topic>Post-exercise</topic><topic>Postexercise recovery</topic><topic>Running</topic><topic>Triglyceride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henderson, Gregory C.</creatorcontrib><creatorcontrib>Martinez Tenorio, Valeria</creatorcontrib><creatorcontrib>Tuazon, Marc A.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Lipids in health and disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henderson, Gregory C.</au><au>Martinez Tenorio, Valeria</au><au>Tuazon, Marc A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute exercise in mice transiently remodels the hepatic lipidome in an intensity-dependent manner</atitle><jtitle>Lipids in health and disease</jtitle><date>2020-10-08</date><risdate>2020</risdate><volume>19</volume><issue>1</issue><spage>1</spage><epage>219</epage><pages>1-219</pages><artnum>219</artnum><issn>1476-511X</issn><eissn>1476-511X</eissn><abstract>Background The content of triacylglycerol (TAG) in the liver is known to rapidly increase after a single bout of exercise followed by recovery to sedentary levels. The response of other hepatic lipids, and acyl chain composition of lipid classes, would provide a deeper understanding of the response of hepatic lipid metabolism to acute exercise. Methods Female mice performed a single bout of continuous exercise (CE), high-intensity interval exercise (HIIE), or no exercise (CON). The total content of various lipids in the liver, and fatty acids within lipid classes, were measured in tissues collected 3 h after exercise (Day 1) and the day following exercise (Day 2). Results The total concentration of TAG rose on Day 1 after exercise (P < 0.05), with a greater elevation in HIIE than CE (P < 0.05), followed by a decline toward CON levels on Day 2. The total concentration of other measured lipid classes was not significantly altered by exercise. However, n-6 polyunsaturated fatty acid relative abundance in diacylglycerol (DAG) was increased by HIIE (P < 0.05). In CON liver, TAG content was positively correlated with DAG and phosphatidylethanolamine (P < 0.05), while these statistical associations were disrupted in exercised mice on Day 1. Conclusions The response of lipid metabolism to exercise involves the coordination of metabolism between various tissues, and the lipid metabolism response to acute exercise places a metabolic burden upon the liver. The present findings describe how the liver copes with this metabolic challenge. The flexibility of the TAG pool size in the liver, and other remodeling of the hepatic lipidome, may be fundamental components of the physiological response to intense exercise. Keywords: Lipidomics, High-intensity interval training, Postexercise recovery, Post-exercise, Intrahepatocellular lipid, Triglyceride</abstract><cop>London</cop><pub>BioMed Central Ltd</pub><pmid>33032600</pmid><doi>10.1186/s12944-020-01395-4</doi><orcidid>https://orcid.org/0000-0003-3505-9953</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Diglycerides Fatty acids Fitness equipment Fitness training programs High-intensity interval training Human subjects Intrahepatocellular lipid Laboratory animals Lipid metabolism Lipidomics Lipids Liver Metabolism Musculoskeletal system Phosphatidylethanolamine Physiological aspects Polyunsaturated fatty acids Post-exercise Postexercise recovery Running Triglyceride |
title | Acute exercise in mice transiently remodels the hepatic lipidome in an intensity-dependent manner |
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