Resistin and prooxidant-antioxidant balance: Markers to discriminate acute coronary syndrome from stable angina

• Published in: ARYA atherosclerosis 2020-03, Vol.16 (2), p.46-54
• Main Authors: Pourmoghaddas, AM, Elahifar, Armin, Darabi, Faramarz, Movahedian, Ahmad, Amirpour, Afshin, Sarrafzadegan, Nizal
• Format: Article
• Language: English
• Subjects: acute coronary syndrome; Acute coronary syndromes; Angina pectoris; Antioxidants; Atherosclerosis; Blood pressure; Cardiovascular disease; Cell adhesion & migration; Cholesterol; Coronary vessels; Cytokines; Diabetes; Endothelium; Inflammation; Insulin resistance; Lipids; Medical imaging; Original; Oxidative stress; Proteins; resistin; Risk factors; Smooth muscle; Studies
• ISSN: 1735-3955; 2251-6638
• DOI: 10.22122/arya.v16i2.1944

The aim of this study was to investigate the role of serum resistin and prooxidant-antioxidant balance (PAB) in ACS occurrence in order to differentiate it from stable angina. [...]we aimed to determine the correlation between resistin and PAB in patients with ACS and its difference from patients with stable CHD. [...]the epicardial adipose tissue (EAT) covers the surface of the heart. In humans, resistin is primarily a product of macrophages.21,22 Resistin is highly expressed in human peripheral blood mononuclear cells and is involved in inflammatory reactions.23 Resistin secreted by macrophages infiltrating the atheromas affects endothelial function and stimulates vascular smooth muscle cells migration.13,17 In chronic inflammatory conditions such as diabetes, obesity, and atherosclerotic CVD, proatherogenic imbalance is observed; this means the serum contains higher adiponectin levels and lower resistin and leptin levels. [...]it seems that ACS-activated inflammation must be categorized as an acute inflammation rather than a chronic inflammation.24 It has been hypothesized that resistin serum level and PAB can predict ACS in patients with CHD. Based on the definition, stenosis in more than 75% of any major coronary arteries or more than 50% of the left main coronary artery cross-sectional area is considered a significant CAD.25,26 All data including age, gender, serum creatinine, lipid profile [total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG)], body mass index (BMI; calculated as weight in kilograms divided by height in meters squared), tobacco use, medication history, hypertension (HTN; defined as systolic blood pressure > 140 mmHg and diastolic blood pressure > 90 mmHg in two consecutive times or consumption of antihypertensive drugs), diabetes mellitus (DM; defined as a fasting blood glucose > 126 mg/ dl and hemoglobin A1C > 6.5%, or use of hypoglycemic medication), and other risk factors of CHD were recorded.