Efficacy of using walnuts as statin adjuvants in hypertension management

Due to the widespread unorthodox use of nuts to improve cardiovascular health, this clinical trial was carried out to evaluate the efficacy of walnut as an adjuvant statin in hypertensive subjects. A single-blind placebo-controlled randomized clinical trial that lasted for 3 months. Forty-five scree...

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Published in:Clinical and experimental hypertension (1993) 2022-07, Vol.44 (5), p.419-426
Main Authors: Amadi, Peter U., Agomuo, Emmanuel N., Amadi, Joy A., Bob-Chile Agada, Adaeze I., Njoku, Uche C., Ogunwa, Chinedu S., Odika, Prince C., Osuoha, Justice O., Ogbolosingha, Atieme J., Adumekwe, Chiamaka W., Chigbu, Ifeyinwa N.
Format: Article
Language:English
Subjects:
Apolipoproteins E
blood pressure
cholesterol
Cholesterol, LDL
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
hypertension
Hypertension - drug therapy
Juglans
Nuts
Proprotein Convertase 9 - metabolism
Single-Blind Method
Statins
walnut
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Summary:Due to the widespread unorthodox use of nuts to improve cardiovascular health, this clinical trial was carried out to evaluate the efficacy of walnut as an adjuvant statin in hypertensive subjects. A single-blind placebo-controlled randomized clinical trial that lasted for 3 months. Forty-five screened hypertensive subjects on treatment, aged 45-65 years, were randomized into intervention and placebo groups according to their blood pressure defined by the American Heart Association criteria. Fifteen (15) normotensive subjects were also recruited for this study. The participants in the intervention group included daily 7 g of boiled walnut taken as snacks. The study was not controlled for type of diet and frequency of meals in a day. Low-density lipoprotein cholesterol (LDLc) was the primary endpoint for this study. The mean LDLc levels of the intervention groups (84.6 mg/dl and 79.7 mg/dl, respectively) were significantly (p 
ISSN:1064-1963
1525-6006
DOI:10.1080/10641963.2022.2065287