HDL-C to hsCRP ratio is associated with left ventricular diastolic function in absence of significant coronary atherosclerosis

High-density lipoprotein cholesterol (HDL-C) is considered as a protective marker of coronary atherosclerotic disease (CAD). It is still not clear if HDL-C is associated with left ventricular (LV) diastolic function in an inflammation-related manner in absence of significant coronary atherosclerosis...

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Published in:Lipids in health and disease 2019-12, Vol.18 (1), p.219-219, Article 219
Main Authors: Sun, Lufan, Liu, Xiaorui, Li, Wenna, Jia, Dalin
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Analysis
Angiography
Arteriosclerosis
Atherosclerosis
Blood pressure
C-reactive protein
C-Reactive Protein - analysis
Cardiac patients
Cardiology
Cardiovascular disease
Cardiovascular risk factor
CAT scans
Chest Pain
Cholesterol
Cholesterol, HDL - blood
Computed tomography
Congestive heart failure
Coronary artery
Coronary Artery Disease - diagnosis
Coronary vessels
Diabetes
Echocardiography
Fasting
Female
Flow velocity
Heart
Heart failure
High density lipoprotein
High-density lipoprotein cholesterol
Hospitals
Humans
Hypertension
Inflammation
Ischemia
Laboratories
Left ventricular diastolic function
Lipoproteins
Male
Medical imaging
Middle Aged
Multiple regression analysis
Plaques
Plasma
Regression analysis
Risk Factors
Sensitivity and Specificity
Statistical analysis
Variance analysis
Veins & arteries
Ventricle
Ventricular Dysfunction, Left - blood
Ventricular Function, Left
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Liu, Xiaorui
Li, Wenna
Jia, Dalin
description High-density lipoprotein cholesterol (HDL-C) is considered as a protective marker of coronary atherosclerotic disease (CAD). It is still not clear if HDL-C is associated with left ventricular (LV) diastolic function in an inflammation-related manner in absence of significant coronary atherosclerosis. 392 patients who complained of chest pain and were suspected of CAD without heart failure were enrolled in this study. Coronary angiography or coronary artery CT scan was performed to detect coronary atherosclerosis. Transthoracic echocardiography was performed to evaluate cardiac function. Plasma level of HDL-C and high-sensitive C-reactive protein (hsCRP) were determined in each subject. Relationship between HDL-C/hsCRP ratio and LV diastolic function in subjects without significant coronary atherosclerosis was investigated. 204 subjects without significant coronary plaques were analyzed finally, including 84 males and 120 females whose ages ranged from 30 to 84 years old. When divided into HDL-C/hsCRP quartiles, those in the fourth quartile demonstrated the best diastolic function (E/e' 10.14 ± 2.87, P = 0.02 ). HDL-C/hsCRP was the most significant factor correlated with E/e' in univariate regression analysis (r = - 0.232, P 
doi_str_mv 10.1186/s12944-019-1157-6
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It is still not clear if HDL-C is associated with left ventricular (LV) diastolic function in an inflammation-related manner in absence of significant coronary atherosclerosis. 392 patients who complained of chest pain and were suspected of CAD without heart failure were enrolled in this study. Coronary angiography or coronary artery CT scan was performed to detect coronary atherosclerosis. Transthoracic echocardiography was performed to evaluate cardiac function. Plasma level of HDL-C and high-sensitive C-reactive protein (hsCRP) were determined in each subject. Relationship between HDL-C/hsCRP ratio and LV diastolic function in subjects without significant coronary atherosclerosis was investigated. 204 subjects without significant coronary plaques were analyzed finally, including 84 males and 120 females whose ages ranged from 30 to 84 years old. When divided into HDL-C/hsCRP quartiles, those in the fourth quartile demonstrated the best diastolic function (E/e' 10.14 ± 2.87, P = 0.02 ). HDL-C/hsCRP was the most significant factor correlated with E/e' in univariate regression analysis (r = - 0.232, P &lt; 0.001) and multiple regression analysis adjusted by other factors (standardized β = - 0.258 , P &lt; 0.0005 ). In logistic regression, HDL-C/hsCRP was proved to be a protective factor of LV diastolic dysfunction E/e' &gt; 14 (OR = 0.649, 95%CI 0.444-0.948,P = 0.025 ). The sensitivity and specificity of using HDL-C/hsCRP &lt; 0.98 to predict LV diastolic dysfunction were 64.3% and 56.2%, respectively. HDL-C/hsCRP ratio presented a reduced trend as increasing rate of CV risk factors. HDL-C/hsCRP ratio strongly correlates with LV diastolic function in absence of significant coronary atherosclerosis. 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It is still not clear if HDL-C is associated with left ventricular (LV) diastolic function in an inflammation-related manner in absence of significant coronary atherosclerosis. 392 patients who complained of chest pain and were suspected of CAD without heart failure were enrolled in this study. Coronary angiography or coronary artery CT scan was performed to detect coronary atherosclerosis. Transthoracic echocardiography was performed to evaluate cardiac function. Plasma level of HDL-C and high-sensitive C-reactive protein (hsCRP) were determined in each subject. Relationship between HDL-C/hsCRP ratio and LV diastolic function in subjects without significant coronary atherosclerosis was investigated. 204 subjects without significant coronary plaques were analyzed finally, including 84 males and 120 females whose ages ranged from 30 to 84 years old. 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Low HDL-C/hsCRP ratio tends to relate with LV diastolic dysfunction.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Angiography</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Blood pressure</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiac patients</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular risk factor</subject><subject>CAT scans</subject><subject>Chest Pain</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - blood</subject><subject>Computed tomography</subject><subject>Congestive heart failure</subject><subject>Coronary artery</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Echocardiography</subject><subject>Fasting</subject><subject>Female</subject><subject>Flow velocity</subject><subject>Heart</subject><subject>Heart failure</subject><subject>High density lipoprotein</subject><subject>High-density lipoprotein cholesterol</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Inflammation</subject><subject>Ischemia</subject><subject>Laboratories</subject><subject>Left ventricular diastolic function</subject><subject>Lipoproteins</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Multiple regression analysis</subject><subject>Plaques</subject><subject>Plasma</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Statistical analysis</subject><subject>Variance analysis</subject><subject>Veins &amp; 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Liu, Xiaorui ; Li, Wenna ; Jia, Dalin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c560t-9f02174bd34b9b98e324a546312a36983272bfffb7b735f651e14e7ca3b1463d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Angiography</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Blood pressure</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiac patients</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular risk factor</topic><topic>CAT scans</topic><topic>Chest Pain</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL - blood</topic><topic>Computed tomography</topic><topic>Congestive heart failure</topic><topic>Coronary artery</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Echocardiography</topic><topic>Fasting</topic><topic>Female</topic><topic>Flow velocity</topic><topic>Heart</topic><topic>Heart failure</topic><topic>High density lipoprotein</topic><topic>High-density lipoprotein cholesterol</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Inflammation</topic><topic>Ischemia</topic><topic>Laboratories</topic><topic>Left ventricular diastolic function</topic><topic>Lipoproteins</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Multiple regression analysis</topic><topic>Plaques</topic><topic>Plasma</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Statistical analysis</topic><topic>Variance analysis</topic><topic>Veins &amp; arteries</topic><topic>Ventricle</topic><topic>Ventricular Dysfunction, Left - blood</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Lufan</creatorcontrib><creatorcontrib>Liu, Xiaorui</creatorcontrib><creatorcontrib>Li, Wenna</creatorcontrib><creatorcontrib>Jia, Dalin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; 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It is still not clear if HDL-C is associated with left ventricular (LV) diastolic function in an inflammation-related manner in absence of significant coronary atherosclerosis. 392 patients who complained of chest pain and were suspected of CAD without heart failure were enrolled in this study. Coronary angiography or coronary artery CT scan was performed to detect coronary atherosclerosis. Transthoracic echocardiography was performed to evaluate cardiac function. Plasma level of HDL-C and high-sensitive C-reactive protein (hsCRP) were determined in each subject. Relationship between HDL-C/hsCRP ratio and LV diastolic function in subjects without significant coronary atherosclerosis was investigated. 204 subjects without significant coronary plaques were analyzed finally, including 84 males and 120 females whose ages ranged from 30 to 84 years old. When divided into HDL-C/hsCRP quartiles, those in the fourth quartile demonstrated the best diastolic function (E/e' 10.14 ± 2.87, P = 0.02 ). HDL-C/hsCRP was the most significant factor correlated with E/e' in univariate regression analysis (r = - 0.232, P &lt; 0.001) and multiple regression analysis adjusted by other factors (standardized β = - 0.258 , P &lt; 0.0005 ). In logistic regression, HDL-C/hsCRP was proved to be a protective factor of LV diastolic dysfunction E/e' &gt; 14 (OR = 0.649, 95%CI 0.444-0.948,P = 0.025 ). The sensitivity and specificity of using HDL-C/hsCRP &lt; 0.98 to predict LV diastolic dysfunction were 64.3% and 56.2%, respectively. HDL-C/hsCRP ratio presented a reduced trend as increasing rate of CV risk factors. HDL-C/hsCRP ratio strongly correlates with LV diastolic function in absence of significant coronary atherosclerosis. Low HDL-C/hsCRP ratio tends to relate with LV diastolic dysfunction.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>31831002</pmid><doi>10.1186/s12944-019-1157-6</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6940-7373</orcidid><oa>free_for_read</oa></addata></record>
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ispartof Lipids in health and disease, 2019-12, Vol.18 (1), p.219-219, Article 219
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subjects Adult
Age
Aged
Aged, 80 and over
Analysis
Angiography
Arteriosclerosis
Atherosclerosis
Blood pressure
C-reactive protein
C-Reactive Protein - analysis
Cardiac patients
Cardiology
Cardiovascular disease
Cardiovascular risk factor
CAT scans
Chest Pain
Cholesterol
Cholesterol, HDL - blood
Computed tomography
Congestive heart failure
Coronary artery
Coronary Artery Disease - diagnosis
Coronary vessels
Diabetes
Echocardiography
Fasting
Female
Flow velocity
Heart
Heart failure
High density lipoprotein
High-density lipoprotein cholesterol
Hospitals
Humans
Hypertension
Inflammation
Ischemia
Laboratories
Left ventricular diastolic function
Lipoproteins
Male
Medical imaging
Middle Aged
Multiple regression analysis
Plaques
Plasma
Regression analysis
Risk Factors
Sensitivity and Specificity
Statistical analysis
Variance analysis
Veins & arteries
Ventricle
Ventricular Dysfunction, Left - blood
Ventricular Function, Left
title HDL-C to hsCRP ratio is associated with left ventricular diastolic function in absence of significant coronary atherosclerosis
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