Feasibility and Efficacy of Morning Light Therapy for Adults with Insomnia: A Pilot, Randomized, Open-Label, Two-Arm Study

Light therapy (LT) is used as an adjunctive treatment for sleep problems. This study evaluates the impact of LT on sleep quality and sleep-related parameters in patients with sleep disorders. We performed a pilot, randomized, open-label clinical trial. Fourteen patients aged 20-60 years with insomni...

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Published in:Medicina (Kaunas, Lithuania) Lithuania), 2023-06, Vol.59 (6), p.1066
Main Authors: Yoon, Jihyun, Heo, Seokjae, Lee, Hyangkyu, Sul, Eungyeong, Han, Taehwa, Kwon, Yu-Jin
Format: Article
Language:English
Subjects:
Adults
Blood pressure
Care and treatment
Cholesterol
Circadian rhythm
Clinical trials
clock genes
daytime sleepiness
Diabetes
Ethylenediaminetetraacetic acid
High density lipoprotein
Homeostasis
Hospitals
Hypertension
Immunoassay
Insomnia
Insulin
Light
Light therapy
Lipoproteins
Mental disorders
Metabolic disorders
Phototherapy
Sleep apnea
sleep disorder
Sleep disorders
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Summary:Light therapy (LT) is used as an adjunctive treatment for sleep problems. This study evaluates the impact of LT on sleep quality and sleep-related parameters in patients with sleep disorders. We performed a pilot, randomized, open-label clinical trial. Fourteen patients aged 20-60 years with insomnia were randomized into the control and LT groups (1:1 ratio). The LT group was instructed to use a device that provides bright LT (6000 K, 380 lux, wavelength 480 nm) for at least 25 min before 09:00 a.m. for two weeks. A self-reported questionnaire was used to evaluate circadian preference, mood, and sleep-related parameters. We analyzed serum cortisol levels and clock genes' expression. The Epworth Sleepiness Scale (ESS), insomnia severity index(ISI), and Pittsburgh Sleep Quality index(PSQI) were significantly improved within the LT group only after the two-week period. When comparing the two groups, only the change in ESS was significant (mean difference, control: -0.14 vs. LT: -1.43, = 0.021) after adjusting for the baseline characteristics. There were no significant differences in serum cortisol or clock genes' expression. LT can improve daytime sleepiness in patients with sleep disorders; however, further well-designed studies are warranted to confirm its efficacy.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina59061066