Experimental Study of Electrical Properties of Pharmaceutical Materials by Electrical Impedance Spectroscopy

The physicochemical characterization of pharmaceutical materials is essential for drug discovery, development and evaluation, and for understanding and predicting their interaction with physiological systems. Amongst many measurement techniques for spectroscopic characterization of pharmaceutical ma...

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Bibliographic Details
Published in:Applied sciences 2020-09, Vol.10 (18), p.6576
Main Authors: Vázquez-Nambo, Manuel, Gutiérrez-Gnecchi, José-Antonio, Reyes-Archundia, Enrique, Yang, Wuqiang, Rodriguez-Frias, Marco-A., Olivares-Rojas, Juan-Carlos, Lorias-Espinoza, Daniel
Format: Article
Language:English
Subjects:
Arrays
Chemical composition
Drug development
drug modelling
Electrical impedance
electrical impedance spectroscopy
Electrical properties
Electrochemical cells
Electrochemistry
Electrodes
Evaluation
Formulations
Frequency ranges
frequency response
Impedance
Impedance spectroscopy
Measurement techniques
Methods
Pharmaceuticals
Physiology
Ranitidine
Software
Spectroscopy
Spectrum analysis
Sulfamethoxazole
System identification
Trimethoprim
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Summary:The physicochemical characterization of pharmaceutical materials is essential for drug discovery, development and evaluation, and for understanding and predicting their interaction with physiological systems. Amongst many measurement techniques for spectroscopic characterization of pharmaceutical materials, Electrical Impedance Spectroscopy (EIS) is powerful as it can be used to model the electrical properties of pure substances and compounds in correlation with specific chemical composition. In particular, the accurate measurement of specific properties of drugs is important for evaluating physiological interaction. The electrochemical modelling of compounds is usually carried out using spectral impedance data over a wide frequency range, to fit a predetermined model of an equivalent electrochemical cell. This paper presents experimental results by EIS analysis of four drug formulations (trimethoprim/sulfamethoxazole C14H18N4O3-C10H11N3O3, ambroxol C13H18Br2N2O.HCl, metamizole sodium C13H16N3NaO4S, and ranitidine C13H22N4O3S.HCl). A wide frequency range from 20 Hz to 30 MHz is used to evaluate system identification techniques using EIS data and to obtain process models. The results suggest that arrays of linear R-C models derived using system identification techniques in the frequency domain can be used to identify different compounds.
ISSN:2076-3417
2076-3417
DOI:10.3390/app10186576