Antibacterial Properties of Visible-Light-Responsive Carbon-Containing Titanium Dioxide Photocatalytic Nanoparticles against Anthrax

The bactericidal activity of conventional titanium dioxide (TiO₂) photocatalyst is effective only on irradiation by ultraviolet light, which restricts the applications of TiO₂ for use in living environments. Recently, carbon-containing TiO₂ nanoparticles [TiO₂(C) NP] were found to be a visible-light...

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Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2016-12, Vol.6 (12), p.237-237
Main Authors: Sun, Der-Shan, Kau, Jyh-Hwa, Huang, Hsin-Hsien, Tseng, Yao-Hsuan, Wu, Wen-Shiang, Chang, Hsin-Hou
Format: Article
Language:English
Subjects:
Anthrax
anthrax spore
antibacterial agents
Antibacterial properties
Bacillus anthracis
Bacteria
Carbon
carbon-containing TiO2
Disinfection & disinfectants
Electrons
Fourier transforms
Inactivation
Irradiation
Light
Macrophages
Nanomaterials
Nanoparticles
Oxidation
Photocatalysis
Physical properties
Reduction
Spectrum analysis
TiO2
Titanium
Titanium dioxide
Toxins
Ultraviolet radiation
visible light responsive photocatalyst
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Summary:The bactericidal activity of conventional titanium dioxide (TiO₂) photocatalyst is effective only on irradiation by ultraviolet light, which restricts the applications of TiO₂ for use in living environments. Recently, carbon-containing TiO₂ nanoparticles [TiO₂(C) NP] were found to be a visible-light-responsive photocatalyst (VLRP), which displayed significantly enhanced antibacterial properties under visible light illumination. However, whether TiO₂(C) NPs exert antibacterial properties against remains elusive. Here, we evaluated these VLRP NPs in the reduction of anthrax-induced pathogenesis. Bacteria-killing experiments indicated that a significantly higher proportion (40%-60%) of all tested species, including , , , and , were considerably eliminated by TiO₂(C) NPs. Toxin inactivation analysis further suggested that the TiO₂(C) NPs efficiently detoxify approximately 90% of tested anthrax lethal toxin, a major virulence factor of anthrax. Notably, macrophage clearance experiments further suggested that, even under suboptimal conditions without considerable bacterial killing, the TiO₂(C) NP-mediated photocatalysis still exhibited antibacterial properties through the reduction of bacterial resistance against macrophage killing. Our results collectively suggested that TiO₂(C) NP is a conceptually feasible anti-anthrax material, and the relevant technologies described herein may be useful in the development of new strategies against anthrax.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano6120237