Long-term Maintenance of CD4 T Cell Memory Responses to Malaria Antigens in Malian Children Coinfected with Schistosoma haematobium

Polyparasitism is common in the developing world. We have previously demonstrated that schistosomiasis-positive (SP) Malian children, aged 4-8 years, are protected from malaria compared to matched schistosomiasis-negative (SN) children. The effect of concomitant schistosomiasis upon acquisition of T...

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Bibliographic Details
Published in:Frontiers in immunology 2018-02, Vol.8, p.1995
Main Authors: Lyke, Kirsten E, Dabo, Abdoulaye, Arama, Charles, Diarra, Issa, Plowe, Christopher V, Doumbo, Ogobara K, Sztein, Marcelo B
Format: Article
Language:English
Subjects:
coinfection
Immunology
malaria
memory
multifunctional T cells
schistosomiasis
T cell memory
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Summary:Polyparasitism is common in the developing world. We have previously demonstrated that schistosomiasis-positive (SP) Malian children, aged 4-8 years, are protected from malaria compared to matched schistosomiasis-negative (SN) children. The effect of concomitant schistosomiasis upon acquisition of T cell memory is unknown. We examined antigen-specific T cell frequencies in 48 Malian children aged 4-14 to a pool of malaria blood stage antigens, and a pool of schistosomal antigens, at a time point during a malaria episode and at a convalescent time point ~6 months later, following cessation of malaria transmission. CD4 T cell-derived memory responses, defined as one or more significant cytokine (IFN-γ, TNF-α, IL-2, and/or IL-17 ) responses, was measured to schistoma antigens in 18/23 SP children at one or both time points, compared to 4/23 SN children (  
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2017.01995