Clostridium butyricum attenuates LPS-induced myocardial injury in septic mice by modulating CD4 + CD25 + FOXP3 + Treg

Sepsis-induced myocardial injury has become a major threat to patient health and safety. Intestinal microbiota imbalance plays a crucial role in sepsis regulation. Using 16srRNA technology, we explored how intestinal colonization of Clostridium butyricum over 28 days impacted mice with LPS-induced s...

Full description

Saved in:
Bibliographic Details
Published in:Immunobiology (1979) 2025-01, Vol.230 (1), p.152857, Article 152857
Main Authors: Zhao, Jinglin, Wu, Liuli, Zhang, Rupan, Yuan, Mei, Huang, Junchao, Jia, Xiongfei, Mao, Xiaoqin
Format: Article
Language:English
Subjects:
Clostridium butyricum
Myocardial injury
Regulatory T-cells
Sepsis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sepsis-induced myocardial injury has become a major threat to patient health and safety. Intestinal microbiota imbalance plays a crucial role in sepsis regulation. Using 16srRNA technology, we explored how intestinal colonization of Clostridium butyricum over 28 days impacted mice with LPS-induced sepsis. Significant changes were noted in the gut microbiota of the mice, highlighting that C. butyricum can positively influence the immune state in septic myocardial injury models. The bacterium's ability to prevent intestinal mucosal damage and alleviate the immunosuppressive state during the later stages of sepsis by regulating CD4 + CD25 + FOXP3 + Treg cells is particularly noteworthy. This suggests a therapeutic role for C. butyricum in sepsis management by protecting against myocardial injury and improving immune regulation. A: Schematic diagram of myocardial injury process in sepsis mice. B: Schematic diagram of Clostridium butyricum reducing myocardial damage in septic. [Display omitted]
ISSN:0171-2985
1878-3279
1878-3279
DOI:10.1016/j.imbio.2024.152857