Editorial: Insulin and The Brain

The role of insulin in the brain has been suggested in the late 1950's based on experiments showing that insulin was able to increase glucose uptake in spinal cord tissue, in several brain regions such as the choroid plexus the pineal gland, and in the pituitary (1). Since then, increasing evid...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2019-05, Vol.10, p.299-299
Main Authors: Taouis, Mohammed, Torres-Aleman, Ignacio
Format: Article
Language:English
Subjects:
brain
cognition
Cognitive Sciences
Endocrinology
insulin
insulin resistance
intranasal
Life Sciences
Neurobiology
neurodegenrative diseases
Neurons and Cognition
Psychology and behavior
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Summary:The role of insulin in the brain has been suggested in the late 1950's based on experiments showing that insulin was able to increase glucose uptake in spinal cord tissue, in several brain regions such as the choroid plexus the pineal gland, and in the pituitary (1). Since then, increasing evidence attributed to insulin action in the brain numerous critical roles in the control of vital physiological functions: energy homeostasis, neuronal plasticity, and growth, lipid, and glucose metabolism through the control of peripheral organs. Furthermore, the alteration of insulin action observed in insulin-resistant state or obesity is considered a risk factor for several pathologies including neurodegenerative diseases and metabolic disorders. Nowadays, many studies aim to decipher the mechanisms of insulin action in different brain regions and the related physio-pathological outputs.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2019.00299