Mitochondrial transfer in tunneling nanotubes-a new target for cancer therapy

A century ago, the Warburg effect was first proposed, revealing that cancer cells predominantly rely on glycolysis during the process of tumorigenesis, even in the presence of abundant oxygen, shifting the main pathway of energy metabolism from the tricarboxylic acid cycle to aerobic glycolysis. Rec...

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Bibliographic Details
Published in:Journal of experimental & clinical cancer research 2024-05, Vol.43 (1), p.147-147, Article 147
Main Authors: Guan, Fan, Wu, Xiaomin, Zhou, Jiatong, Lin, Yuzhe, He, Yuqing, Fan, Chunmei, Zeng, Zhaoyang, Xiong, Wei
Format: Article
Language:English
Subjects:
Animals
Cancer
Cancer therapies
Cardiomyocytes
Cells
Chemotherapy
Chemotherapy resistance
Extracellular vesicles
Gliomas
Glucose metabolism
Health aspects
Humans
Immune evasion
Immunotherapy
Kinases
Metabolic symbiosis
Metabolism
Metabolites
Metastasis
MicroRNAs
Microscopy
Mitochondria
Mitochondria - metabolism
Mitochondrial DNA
Mitochondrial transfer
Nanotubes
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Neoplasms - therapy
Oxidative phosphorylation
Phosphorylation
Physiology
Proteins
Review
T cells
Tumor Microenvironment
Tumors
Tunneling nanotubes
Vincristine
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Summary:A century ago, the Warburg effect was first proposed, revealing that cancer cells predominantly rely on glycolysis during the process of tumorigenesis, even in the presence of abundant oxygen, shifting the main pathway of energy metabolism from the tricarboxylic acid cycle to aerobic glycolysis. Recent studies have unveiled the dynamic transfer of mitochondria within the tumor microenvironment, not only between tumor cells but also between tumor cells and stromal cells, immune cells, and others. In this review, we explore the pathways and mechanisms of mitochondrial transfer within the tumor microenvironment, as well as how these transfer activities promote tumor aggressiveness, chemotherapy resistance, and immune evasion. Further, we discuss the research progress and potential clinical significance targeting these phenomena. We also highlight the therapeutic potential of targeting intercellular mitochondrial transfer as a future anti-cancer strategy and enhancing cell-mediated immunotherapy.
ISSN:1756-9966
0392-9078
1756-9966
DOI:10.1186/s13046-024-03069-w