Racial and Ethnic Differences in Sociodemographic, Clinical, and Treatment Characteristics Among Patients with Atopic Dermatitis in the United States and Canada: Real-World Data from the CorEvitas Atopic Dermatitis Registry

• Published in: Dermatology and therapy 2023-09, Vol.13 (9), p.2045-2061
• Main Authors: Silverberg, Jonathan I., Shi, Vivian Y., Alexis, Andrew, Pierce, Evangeline, Cronin, Angel, McLean, Robert R., Roberts-Toler, Carla, Rueda, Maria J, Atwater, Amber R., Simpson, Eric
• Format: Article
• Language: English
• Subjects: Atopic dermatitis; Demographic aspects; Dermatology; Drug therapy; Ethnic; Ethnicity; Health aspects; Health care disparities; Internal Medicine; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Minorities; Oral and Maxillofacial Surgery; Original Research; Patient-reported outcomes; Patterns; Plastic Surgery; Quality of Life Research; Race; Racial; Sociodemographic; Statistics
• ISSN: 2193-8210; 2190-9172
• DOI: 10.1007/s13555-023-00980-6

Introduction This real-world, cross-sectional study compared sociodemographic, clinical and treatment characteristics, and patient-reported outcomes (PROs) among racial/ethnic groups in patients with atopic dermatitis (AD) who are candidates for systemic therapy. Methods This study included adults with dermatologist- or dermatology practitioner-diagnosed AD enrolled in the CorEvitas AD Registry (July 2020–July 2021). All patients initiated systemic therapy within 12 months prior to or at enrollment or had moderate-to-severe AD (vIGA-AD ®  ≥ 3 and Eczema Area and Severity Index [EASI] ≥ 12) at enrollment. Patients were categorized into five mutually exclusive racial/ethnic groups: non-Hispanic White, Black, Asian, Other/Multiracial, and Hispanic (any race). Patient, clinical, and treatment characteristics were captured at enrollment. Differences in means or proportions of characteristics among racial/ethnic groups were descriptively summarized using effect sizes. Adjusted prevalence ratios and mean differences were estimated (White race/ethnicity group as the reference category) with 95% confidence intervals (CI). Results Among 1288 patients, 64% ( n  = 822) were White, 13% ( n  = 167) Black, 10% ( n  = 129) Asian, 8% ( n  = 97) Hispanic, and 6% ( n  = 73) Other/Multiracial. In adjusted analyses, statistically more severe EASI lichenification was noted among Black compared with White patients at the head and neck (mean difference, 0.21, [95% CI 0.06, 0.36]; p  = 0.01), trunk (0.32, [0.17, 0.47]; p