Contrasting regulation of live Bacillus cereus No.1 and its volatiles on Shiraia perylenequinone production

Fungal perylenequinones (PQs) are a class of photoactivated polyketide mycotoxins produced by plant-associated fungi. Hypocrellins, the effective anticancer photodynamic therapy (PDT) agents are main bioactive PQs isolated from a bambusicolous Shiraia fruiting bodies. We found previously that bacter...

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Bibliographic Details
Published in:Microbial cell factories 2022-08, Vol.21 (1), p.1-172, Article 172
Main Authors: Xu, Rui, Li, Xin Ping, Zhang, Xiang, Shen, Wen Hao, Min, Chun Yan, Wang, Jian Wen
Format: Article
Language:English
Subjects:
Anticancer properties
Bacillus
Bacillus cereus
Bacteria
Biodegradation
Biological activity
Biomass
Biosynthesis
Co-culture
Direct contact
Fruit bodies
Fungi
Gas chromatography
Gene regulation
Health aspects
Hypocrellin
Investigations
Metabolites
Methods
Mycotoxins
Organic compounds
Photodynamic therapy
Shiraia
VOCs
Volatile compounds
Volatile organic compounds
Volatiles
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Summary:Fungal perylenequinones (PQs) are a class of photoactivated polyketide mycotoxins produced by plant-associated fungi. Hypocrellins, the effective anticancer photodynamic therapy (PDT) agents are main bioactive PQs isolated from a bambusicolous Shiraia fruiting bodies. We found previously that bacterial communities inhabiting fungal fruiting bodies are diverse, but with unknown functions. Bacillus is the most dominant genus inside Shiraia fruiting body. To understand the regulation role of the dominant Bacillus isolates on host fungus, we continued our work on co-culture of the dominant bacterium B. cereus No.1 with host fungus Shiraia sp. S9 to elucidate bacterial regulation on fungal hypocrellin production. Our results indicated that bacterial volatile release could be a long-distance signal to elicit fungal PQ production. Biodegradation and inhibition by direct contact on fungal PQs were induced by the dominate Bacillus to protect themselves in the fruiting bodies. This is the first report on the regulation of Bacillus volatiles on fungal PQ production. These findings could be helpful for both understanding the intimate fungal-bacterial interactions in a fruiting body and establishing novel cultures for the enhanced production of bioactive PQs.
ISSN:1475-2859
1475-2859
DOI:10.1186/s12934-022-01897-z