Dual Regulation Mechanism of Obesity: DNA Methylation and Intestinal Flora

Obesity is a multifactorial chronic inflammatory metabolic disorder, with pathogenesis influenced by genetic and non-genetic factors such as environment and diet. Intestinal microbes and their metabolites play significant roles in the occurrence and development of obesity by regulating energy metabo...

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Bibliographic Details
Published in:Biomedicines 2024-07, Vol.12 (8), p.1633
Main Authors: Ren, Yi, Huang, Peng, Zhang, Lu, Tang, Yu-Fen, Luo, Sen-Lin, She, Zhou, Peng, Hong, Chen, Yu-Qiong, Luo, Jin-Wen, Duan, Wang-Xin, Liu, Ling-Juan, Liu, Li-Qun
Format: Article
Language:English
Subjects:
Autoimmune diseases
Development and progression
Diabetes
Disease
DNA
DNA methylation
Energy metabolism
Epigenetic inheritance
Epigenetics
Gene expression
Genes
Genetic factors
Genetic research
Genomes
Genomics
Health risk assessment
Inflammation
Insulin resistance
intestinal flora
Intestinal microflora
Life expectancy
Metabolic disorders
Metabolism
Metabolites
Methylation
Microbiota
Microbiota (Symbiotic organisms)
Nucleotide sequence
Obesity
Pathogenesis
Physiological aspects
Pregnancy
Proteins
Review
Risk factors
Type 2 diabetes
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Summary:Obesity is a multifactorial chronic inflammatory metabolic disorder, with pathogenesis influenced by genetic and non-genetic factors such as environment and diet. Intestinal microbes and their metabolites play significant roles in the occurrence and development of obesity by regulating energy metabolism, inducing chronic inflammation, and impacting intestinal hormone secretion. Epigenetics, which involves the regulation of host gene expression without changing the nucleotide sequence, provides an exact direction for us to understand how the environment, lifestyle factors, and other risk factors contribute to obesity. DNA methylation, as the most common epigenetic modification, is involved in the pathogenesis of various metabolic diseases. The epigenetic modification of the host is induced or regulated by the intestinal microbiota and their metabolites, linking the dynamic interaction between the microbiota and the host genome. In this review, we examined recent advancements in research, focusing on the involvement of intestinal microbiota and DNA methylation in the etiology and progression of obesity, as well as potential interactions between the two factors, providing novel perspectives and avenues for further elucidating the pathogenesis, prevention, and treatment of obesity.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12081633