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Intravenous antibiotics in preterm infants have a negative effect upon microbiome development throughout preterm life
Intestinal dysbiosis is implicated in the origins of necrotising enterocolitis and late-onset sepsis in preterm babies. However, the effect of modulators of bacterial growth (e.g. antibiotics) upon the developing microbiome is not well-characterised. In this prospectively-recruited, retrospectively-...
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| Published in: | Gut pathogens 2023-04, Vol.15 (1), p.18-18, Article 18 |
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| creator | Hutchinson, R A Costeloe, K L Wade, W G Millar, M R Ansbro, K Stacey, F Fleming, P F |
| description | Intestinal dysbiosis is implicated in the origins of necrotising enterocolitis and late-onset sepsis in preterm babies. However, the effect of modulators of bacterial growth (e.g. antibiotics) upon the developing microbiome is not well-characterised. In this prospectively-recruited, retrospectively-classified, case-control study, high-throughput 16S rRNA gene sequencing was combined with contemporaneous clinical data collection, to assess the within-subject relationship between antibiotic administration and microbiome development, in comparison to preterm infants with minimal antibiotic exposure.
During courses of antibiotics, diversity progression fell in comparison to that seen outside periods of antibiotic use (-0.71units/week vs. + 0.63units/week, p |
| doi_str_mv | 10.1186/s13099-023-00544-1 |
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During courses of antibiotics, diversity progression fell in comparison to that seen outside periods of antibiotic use (-0.71units/week vs. + 0.63units/week, p < 0.01); Enterobacteriaceae relative abundance progression conversely rose (+ 10.6%/week vs. -8.9%/week, p < 0.01). After antibiotic cessation, diversity progression remained suppressed (+ 0.2units/week, p = 0.02).
Antibiotic use has an acute and longer-lasting impact on the developing preterm intestinal microbiome. This has clinical implications with regard to the contribution of antibiotic use to evolving dysbiosis, and affects the interpretation of existing microbiome studies where this effect modulator is rarely accounted for.</description><identifier>ISSN: 1757-4749</identifier><identifier>EISSN: 1757-4749</identifier><identifier>DOI: 10.1186/s13099-023-00544-1</identifier><identifier>PMID: 37085896</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Analysis ; Antibiotics ; Birth weight ; Dysbacteriosis ; Enterocolitis ; Gestational age ; Infants ; Infants (Premature) ; Infection ; Intestine ; Microbiomes ; Necrotizing enterocolitis ; Neonates ; Newborn babies ; Population ; Premature babies ; RNA ; rRNA 16S ; Sepsis ; Trends</subject><ispartof>Gut pathogens, 2023-04, Vol.15 (1), p.18-18, Article 18</ispartof><rights>2023. The Author(s).</rights><rights>COPYRIGHT 2023 BioMed Central Ltd.</rights><rights>2023. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c633t-d42ad4ccc6a976237a3438c8e8fb870811a45cdc298779a0ddadd51b11d5fd803</citedby><cites>FETCH-LOGICAL-c633t-d42ad4ccc6a976237a3438c8e8fb870811a45cdc298779a0ddadd51b11d5fd803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120188/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2815638067?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37085896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hutchinson, R A</creatorcontrib><creatorcontrib>Costeloe, K L</creatorcontrib><creatorcontrib>Wade, W G</creatorcontrib><creatorcontrib>Millar, M R</creatorcontrib><creatorcontrib>Ansbro, K</creatorcontrib><creatorcontrib>Stacey, F</creatorcontrib><creatorcontrib>Fleming, P F</creatorcontrib><title>Intravenous antibiotics in preterm infants have a negative effect upon microbiome development throughout preterm life</title><title>Gut pathogens</title><addtitle>Gut Pathog</addtitle><description>Intestinal dysbiosis is implicated in the origins of necrotising enterocolitis and late-onset sepsis in preterm babies. However, the effect of modulators of bacterial growth (e.g. antibiotics) upon the developing microbiome is not well-characterised. In this prospectively-recruited, retrospectively-classified, case-control study, high-throughput 16S rRNA gene sequencing was combined with contemporaneous clinical data collection, to assess the within-subject relationship between antibiotic administration and microbiome development, in comparison to preterm infants with minimal antibiotic exposure.
During courses of antibiotics, diversity progression fell in comparison to that seen outside periods of antibiotic use (-0.71units/week vs. + 0.63units/week, p < 0.01); Enterobacteriaceae relative abundance progression conversely rose (+ 10.6%/week vs. -8.9%/week, p < 0.01). After antibiotic cessation, diversity progression remained suppressed (+ 0.2units/week, p = 0.02).
Antibiotic use has an acute and longer-lasting impact on the developing preterm intestinal microbiome. This has clinical implications with regard to the contribution of antibiotic use to evolving dysbiosis, and affects the interpretation of existing microbiome studies where this effect modulator is rarely accounted for.</description><subject>Analysis</subject><subject>Antibiotics</subject><subject>Birth weight</subject><subject>Dysbacteriosis</subject><subject>Enterocolitis</subject><subject>Gestational age</subject><subject>Infants</subject><subject>Infants (Premature)</subject><subject>Infection</subject><subject>Intestine</subject><subject>Microbiomes</subject><subject>Necrotizing enterocolitis</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Population</subject><subject>Premature babies</subject><subject>RNA</subject><subject>rRNA 16S</subject><subject>Sepsis</subject><subject>Trends</subject><issn>1757-4749</issn><issn>1757-4749</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkl-L3CAUxUNp6W63_QJ9KIFC6Uu2GjXRp7Is_TOw0Jf2WYzeJA6JpmoG-u3r7GyHmTL44EV_9yT3eIriLUa3GPPmU8QECVGhmlQIMUor_Ky4xi1rK9pS8fykvipexbhFqKGUs5fFFWkRZ1w018W6cSmoHTi_xlK5ZDvrk9WxtK5cAiQIcy77fBPLMXOlKh0MKtlcQt-DTuW6eFfOVgefe2coDexg8ssMLpVpDH4dRr-mo9pke3hdvOjVFOHN035T_Pr65ef99-rhx7fN_d1DpRtCUmVorQzVWjdKtE1NWkUo4ZoD7zueR8BYUaaNrgVvW6GQMcoYhjuMDesNR-Sm2Bx0jVdbuQQ7q_BHemXl44EPg1QhjzuBVA30giFTI1pTLLoODAikWI9FKwRmWevzQWtZuxmMhr1x05no-Y2zoxz8TmKEa4Q5zwofnxSC_71CTHK2UcM0KQfZfllzxFAtBGkz-v4_dOvX4LJXmcKsIRw1J9Sg8gT5mXz-sN6LyruWNowwjnCmqgvUAA7yX3oHvc3HZ_ztBT4vA_mVLzZ8OGkYQU1pjH5ak_UunoP1AcxZiTFAf3QPI7mPtDxEWuZIy8dIy33Tu1Pfjy3_Mkz-AlX58cI</recordid><startdate>20230421</startdate><enddate>20230421</enddate><creator>Hutchinson, R A</creator><creator>Costeloe, K L</creator><creator>Wade, W G</creator><creator>Millar, M R</creator><creator>Ansbro, K</creator><creator>Stacey, F</creator><creator>Fleming, P F</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20230421</creationdate><title>Intravenous antibiotics in preterm infants have a negative effect upon microbiome development throughout preterm life</title><author>Hutchinson, R A ; 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However, the effect of modulators of bacterial growth (e.g. antibiotics) upon the developing microbiome is not well-characterised. In this prospectively-recruited, retrospectively-classified, case-control study, high-throughput 16S rRNA gene sequencing was combined with contemporaneous clinical data collection, to assess the within-subject relationship between antibiotic administration and microbiome development, in comparison to preterm infants with minimal antibiotic exposure.
During courses of antibiotics, diversity progression fell in comparison to that seen outside periods of antibiotic use (-0.71units/week vs. + 0.63units/week, p < 0.01); Enterobacteriaceae relative abundance progression conversely rose (+ 10.6%/week vs. -8.9%/week, p < 0.01). After antibiotic cessation, diversity progression remained suppressed (+ 0.2units/week, p = 0.02).
Antibiotic use has an acute and longer-lasting impact on the developing preterm intestinal microbiome. This has clinical implications with regard to the contribution of antibiotic use to evolving dysbiosis, and affects the interpretation of existing microbiome studies where this effect modulator is rarely accounted for.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>37085896</pmid><doi>10.1186/s13099-023-00544-1</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Gut pathogens, 2023-04, Vol.15 (1), p.18-18, Article 18 |
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| subjects | Analysis Antibiotics Birth weight Dysbacteriosis Enterocolitis Gestational age Infants Infants (Premature) Infection Intestine Microbiomes Necrotizing enterocolitis Neonates Newborn babies Population Premature babies RNA rRNA 16S Sepsis Trends |
| title | Intravenous antibiotics in preterm infants have a negative effect upon microbiome development throughout preterm life |
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