Dietary potato peel extract reduces the toxicity of cholesterol oxidation products in rats

• Published in: Journal of functional foods 2016-12, Vol.27, p.461-471
• Main Authors: Hsieh, You-Liang, Yeh, Yen-Hung, Lee, Ya-Ting, Huang, Chih-Yang
• Format: Article
• Language: English
• Subjects: Cholesterol oxidation products; Hepatoprotective; Polyphenol; Potato peel; Rats; Toxicity
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2016.09.019

•Cholesterol oxidation products are found in many processed foods.•Potato peel extract is a source of bioactive components in foods.•Potato peel extract decreases cholesterol oxidation products in rats.•Potato peel extract increases antioxidant enzymes activities in rats.•Caffeic acid and chlorogenic acid are predominant components in potato peel extract. We determined the polyphenolic profiles of the potato peel by HPLC. To elucidate the effect of potato peel extract (PPE) on the toxicity of cholesterol oxidation products (COPs) in rats, a synthetic polyphenolic mixture was prepared, mimicking the composition of PPE. Six groups were treated with a control diet, an oxidized cholesterol diet, a PPE diet, an oxidized cholesterol plus PPE diet, and various doses (1–3%) of the PPE diet. After treatment, significantly increased liver glutathione and trolox equivalent antioxidant capacity levels; superoxide dismutase, catalase, and glutathione peroxidase activities; and mRNA expression were observed in the rats treated with 2% and 3% doses of the PPE diet and significantly decreased aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, blood urea nitrogen, creatinine, and COPs levels were observed compared with the control rats. These results demonstrated the PPE diet reduction in the long-term toxicity of COPs was significant in rats.