First Detection of SARS-CoV-2 Delta (B.1.617.2) Variant of Concern in a Dog with Clinical Signs in Spain

Several cases of naturally infected dogs with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported despite the apparently low susceptibility of this species. Here, we document the first reported case of infection caused by the Delta (B.1.617.2) variant of concern (VOC) in...

Full description

Saved in:
Bibliographic Details
Published in:Viruses 2021-12, Vol.13 (12), p.2526
Main Authors: Fernández-Bastit, Leira, Rodon, Jordi, Pradenas, Edwards, Marfil, Silvia, Trinité, Benjamin, Parera, Mariona, Roca, Núria, Pou, Anna, Cantero, Guillermo, Lorca-Oró, Cristina, Carrillo, Jorge, Izquierdo-Useros, Nuria, Clotet, Bonaventura, Noguera-Julián, Marc, Blanco, Julià, Vergara-Alert, Júlia, Segalés, Joaquim
Format: Article
Language:English
Subjects:
Animals
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
B.1.617.2
Case Report
Coronaviruses
COVID-19
COVID-19 - diagnosis
COVID-19 - transmission
COVID-19 - veterinary
COVID-19 - virology
Delta variant
Disease transmission
dog
Dog Diseases - diagnosis
Dog Diseases - transmission
Dog Diseases - virology
Dogs
Female
Genome, Viral - genetics
Genomes
Infections
Infectious diseases
Pandemics
Pets - virology
Plasma
Protein expression
Proteins
RNA polymerase
Sampling
SARS-CoV-2
SARS-CoV-2 - genetics
SARS-CoV-2 - immunology
SARS-CoV-2 - isolation & purification
Severe acute respiratory syndrome coronavirus 2
variants of concern
Viral Zoonoses - diagnosis
Viral Zoonoses - transmission
Viral Zoonoses - virology
Virulence
Whole genome sequencing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several cases of naturally infected dogs with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported despite the apparently low susceptibility of this species. Here, we document the first reported case of infection caused by the Delta (B.1.617.2) variant of concern (VOC) in a dog in Spain that lived with several household members suffering from Coronavirus Infectious Disease 2019 (COVID-19). The animal displayed mild digestive and respiratory clinical signs and had a low viral load in the oropharyngeal swab collected at the first sampling. Whole-genome sequencing indicated infection with the Delta variant, coinciding with the predominant variant during the fifth pandemic wave in Spain. The dog seroconverted, as detected 21 days after the first sampling, and developed neutralizing antibodies that cross-neutralized different SARS-CoV-2 variants. This study further emphasizes the importance of studying the susceptibility of animal species to different VOCs and their potential role as reservoirs in the context of COVID-19.
ISSN:1999-4915
1999-4915
DOI:10.3390/v13122526