High seroprevalence of antibodies against human respiratory syncytial virus and evidence of respiratory syncytial virus reinfection in young children in Thailand

•Respiratory syncytial virus (RSV) maternal antibodies were efficiently transferred to neonates.•Anti-RSV immunoglobulin G levels increased with age due to natural infection.•Children appear to be highly susceptible to RSV reinfections.•Children aged 90% of babies at birth were seropositive through...

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Bibliographic Details
Published in:International journal of infectious diseases 2022-12, Vol.125, p.177-183
Main Authors: Pasittungkul, Siripat, Thongpan, Ilada, Vichaiwattana, Preeyaporn, Thongmee, Thanunrat, Klinfueng, Sirapa, Suntronwong, Nungruthai, Wanlapakorn, Nasamon, Vongpunsawad, Sompong, Poovorawan, Yong
Format: Article
Language:English
Subjects:
Infants
Reinfection
RSV
Seroprevalence
Young children
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Summary:•Respiratory syncytial virus (RSV) maternal antibodies were efficiently transferred to neonates.•Anti-RSV immunoglobulin G levels increased with age due to natural infection.•Children appear to be highly susceptible to RSV reinfections.•Children aged 90% of babies at birth were seropositive through transplacental transfer, antibody levels gradually declined, with the highest seronegative rate (91.9%) at 7 months of age. Subsequently, anti-RSV IgG levels increased with age, most likely due to natural infection. One-third of the children showed evidence of reinfection as determined by seroconversion of anti-RSV IgG or increased titers of at least 50 relative units/ml. Waning of RSV antibodies in infants is rapid, and RSV infection subsequently increases anti-RSV IgG titers. RSV vaccination in children before the age of 7 months should be recommended.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2022.10.039