Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer

Metabolic rewiring and the consequent production of reactive oxygen species (ROS) are necessary to promote tumorigenesis. At the nexus of these cellular processes is the aberrant regulation of oncogenic signaling cascades such as the phosphoinositide 3-kinase and AKT (PI3K/Akt) pathway, which is one...

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Bibliographic Details
Published in:Frontiers in oncology 2018-05, Vol.8, p.160
Main Authors: Koundouros, Nikos, Poulogiannis, George
Format: Article
Language:English
Subjects:
cancer
metabolism
Oncology
oxidative stress
phosphoinositide 3-kinase/Akt signaling
reactive oxygen species
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