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Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats
Datura stramonium L. (Solanaceae) is used traditionally in west Africa to treat asthma, epilepsy, rheumatoid arthritis, filariasis microbial infections and conjunctivitis. This study investigated the immunomodulatory effects of aqueous seed extract of D. stramonium L. (ASEDS) on Wistar rats. Thirty...
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| Published in: | BMC immunology 2022-10, Vol.23 (1), p.50-19, Article 50 |
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| creator | Joshua, Parker Elijah Yahaya, Junaidu Ekpo, Daniel Emmanuel Ogidigo, Joyce Oloaigbe Odiba, Arome Solomon Asomadu, Rita Onyekachukwu Oka, Samson Ayodeji Adeniyi, Olasupo Stephen |
| description | Datura stramonium L. (Solanaceae) is used traditionally in west Africa to treat asthma, epilepsy, rheumatoid arthritis, filariasis microbial infections and conjunctivitis. This study investigated the immunomodulatory effects of aqueous seed extract of D. stramonium L. (ASEDS) on Wistar rats.
Thirty Wistar albino rats (180-200 g) were randomized into 6 groups (n = 5). Group 1 received distilled water only. Rats in groups 2-6 were pretreated with 10 mg/kg body weight (b.w.) Cyclophosphamide orally for 27-days to induce immunosuppression. Thereafter, they received treatment orally for 28 days as follows: Group 2 (distilled water), group 3 (5 mg/kg b.w. Levamisole), groups 4-6 (60, 90 and 120 mg/kg b.w. ASEDS, respectively). HPLC was used to determine major compounds in ASEDS. The effects of ASEDS on immune cells, immunoglobulins A, G and M levels, lipoproteins, and antioxidant status of rats were evaluated.
ASEDS indicated high content of Acutumine, Quinine, Catechin, Chlorogenic acid, Gallic acid, Quercetin, Vanillic acid, Luteolin, Formosanin C, Saponin, Cyanidin, Tannic acid, 3-Carene, Limonene and α-terpineol. Cyclophosphamide triggered significant (p |
| doi_str_mv | 10.1186/s12865-022-00519-y |
| format | article |
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Thirty Wistar albino rats (180-200 g) were randomized into 6 groups (n = 5). Group 1 received distilled water only. Rats in groups 2-6 were pretreated with 10 mg/kg body weight (b.w.) Cyclophosphamide orally for 27-days to induce immunosuppression. Thereafter, they received treatment orally for 28 days as follows: Group 2 (distilled water), group 3 (5 mg/kg b.w. Levamisole), groups 4-6 (60, 90 and 120 mg/kg b.w. ASEDS, respectively). HPLC was used to determine major compounds in ASEDS. The effects of ASEDS on immune cells, immunoglobulins A, G and M levels, lipoproteins, and antioxidant status of rats were evaluated.
ASEDS indicated high content of Acutumine, Quinine, Catechin, Chlorogenic acid, Gallic acid, Quercetin, Vanillic acid, Luteolin, Formosanin C, Saponin, Cyanidin, Tannic acid, 3-Carene, Limonene and α-terpineol. Cyclophosphamide triggered significant (p < 0.05) reduction in total leucocyte count and differentials, IgA, IgG, high-density lipoproteins (HDL), catalase, superoxide dismutase, glutathione peroxidase, vitamins A, C and E levels of untreated rats. Administration of ASEDS led to significant (p < 0.05) improvement in immune cell counts, immunoglobulin synthesis, high-density lipoprotein concentration, and antioxidant status of rats in the treated groups.
The results obtained from the study showed the immunomodulatory activity of ASEDS, thereby indicating its potential in immunostimulatory drug discovery.</description><identifier>ISSN: 1471-2172</identifier><identifier>EISSN: 1471-2172</identifier><identifier>DOI: 10.1186/s12865-022-00519-y</identifier><identifier>PMID: 36261807</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>3-Carene ; Acids ; Animals ; Antigens ; Antioxidants ; Antioxidants - pharmacology ; Asthma ; Body weight ; Catalase ; Catechin ; Chemical properties ; Chlorogenic Acid ; Complications and side effects ; Conjunctivitis ; Cyclophosphamide ; Cytokines ; Datura stramonium ; Datura stramonium L ; Drug dosages ; Enzymes ; Epilepsy ; Filariasis ; Flavonoids ; Gallic acid ; Gallic Acid - pharmacology ; Glutathione Peroxidase ; Health aspects ; Immune response ; Immune system ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulins ; Immunological research ; Immunomodulation ; Immunostimulation ; Immunosuppression ; Immunosuppression Therapy ; Jimson weed ; Levamisole ; Limonene ; Lipoproteins ; Lipoproteins, HDL ; Luteolin ; Materia medica, Vegetable ; Medicinal plants ; Phytochemicals ; Plant extracts ; Plant Extracts - pharmacology ; Quercetin ; Quinine ; Rats ; Rats, Wistar ; Rheumatoid arthritis ; Rodents ; Saponins ; Seeds ; Superoxide Dismutase ; Tannins ; Tumor necrosis factor-TNF ; Vanillic Acid ; Vitamins ; Water</subject><ispartof>BMC immunology, 2022-10, Vol.23 (1), p.50-19, Article 50</ispartof><rights>2022. The Author(s).</rights><rights>COPYRIGHT 2022 BioMed Central Ltd.</rights><rights>2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c597t-54592d17fc64067e869c404872529014a1becd0ca4237382617dbcaada8b8f923</citedby><cites>FETCH-LOGICAL-c597t-54592d17fc64067e869c404872529014a1becd0ca4237382617dbcaada8b8f923</cites><orcidid>0000-0002-2424-1488 ; 0000-0002-1837-0312 ; 0000-0002-4269-1562 ; 0000-0003-3323-0657 ; 0000-0001-5648-441X ; 0000-0001-9201-8811</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583546/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2730811802?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36261807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Joshua, Parker Elijah</creatorcontrib><creatorcontrib>Yahaya, Junaidu</creatorcontrib><creatorcontrib>Ekpo, Daniel Emmanuel</creatorcontrib><creatorcontrib>Ogidigo, Joyce Oloaigbe</creatorcontrib><creatorcontrib>Odiba, Arome Solomon</creatorcontrib><creatorcontrib>Asomadu, Rita Onyekachukwu</creatorcontrib><creatorcontrib>Oka, Samson Ayodeji</creatorcontrib><creatorcontrib>Adeniyi, Olasupo Stephen</creatorcontrib><title>Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats</title><title>BMC immunology</title><addtitle>BMC Immunol</addtitle><description>Datura stramonium L. (Solanaceae) is used traditionally in west Africa to treat asthma, epilepsy, rheumatoid arthritis, filariasis microbial infections and conjunctivitis. This study investigated the immunomodulatory effects of aqueous seed extract of D. stramonium L. (ASEDS) on Wistar rats.
Thirty Wistar albino rats (180-200 g) were randomized into 6 groups (n = 5). Group 1 received distilled water only. Rats in groups 2-6 were pretreated with 10 mg/kg body weight (b.w.) Cyclophosphamide orally for 27-days to induce immunosuppression. Thereafter, they received treatment orally for 28 days as follows: Group 2 (distilled water), group 3 (5 mg/kg b.w. Levamisole), groups 4-6 (60, 90 and 120 mg/kg b.w. ASEDS, respectively). HPLC was used to determine major compounds in ASEDS. The effects of ASEDS on immune cells, immunoglobulins A, G and M levels, lipoproteins, and antioxidant status of rats were evaluated.
ASEDS indicated high content of Acutumine, Quinine, Catechin, Chlorogenic acid, Gallic acid, Quercetin, Vanillic acid, Luteolin, Formosanin C, Saponin, Cyanidin, Tannic acid, 3-Carene, Limonene and α-terpineol. Cyclophosphamide triggered significant (p < 0.05) reduction in total leucocyte count and differentials, IgA, IgG, high-density lipoproteins (HDL), catalase, superoxide dismutase, glutathione peroxidase, vitamins A, C and E levels of untreated rats. Administration of ASEDS led to significant (p < 0.05) improvement in immune cell counts, immunoglobulin synthesis, high-density lipoprotein concentration, and antioxidant status of rats in the treated groups.
The results obtained from the study showed the immunomodulatory activity of ASEDS, thereby indicating its potential in immunostimulatory drug discovery.</description><subject>3-Carene</subject><subject>Acids</subject><subject>Animals</subject><subject>Antigens</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Asthma</subject><subject>Body weight</subject><subject>Catalase</subject><subject>Catechin</subject><subject>Chemical properties</subject><subject>Chlorogenic Acid</subject><subject>Complications and side effects</subject><subject>Conjunctivitis</subject><subject>Cyclophosphamide</subject><subject>Cytokines</subject><subject>Datura stramonium</subject><subject>Datura stramonium L</subject><subject>Drug dosages</subject><subject>Enzymes</subject><subject>Epilepsy</subject><subject>Filariasis</subject><subject>Flavonoids</subject><subject>Gallic acid</subject><subject>Gallic Acid - pharmacology</subject><subject>Glutathione Peroxidase</subject><subject>Health aspects</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulins</subject><subject>Immunological research</subject><subject>Immunomodulation</subject><subject>Immunostimulation</subject><subject>Immunosuppression</subject><subject>Immunosuppression Therapy</subject><subject>Jimson weed</subject><subject>Levamisole</subject><subject>Limonene</subject><subject>Lipoproteins</subject><subject>Lipoproteins, HDL</subject><subject>Luteolin</subject><subject>Materia medica, Vegetable</subject><subject>Medicinal plants</subject><subject>Phytochemicals</subject><subject>Plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Quercetin</subject><subject>Quinine</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rheumatoid arthritis</subject><subject>Rodents</subject><subject>Saponins</subject><subject>Seeds</subject><subject>Superoxide Dismutase</subject><subject>Tannins</subject><subject>Tumor necrosis factor-TNF</subject><subject>Vanillic Acid</subject><subject>Vitamins</subject><subject>Water</subject><issn>1471-2172</issn><issn>1471-2172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptksuKFDEUhgtRnHH0BVxIwI0uqk1SuW6EYbw1tAhecBnSSao7TVVSk1SJ_Ry-sKnpdpwWySLh5Dv_IX_-qnqK4AIhwV5lhAWjNcS4hpAiWe_vVeeIcFRjxPH9O-ez6lHOOwgRF1g8rM4ahhkSkJ9Xvz5GO3V69DGA2ALf91OIXdx4ozuQXB5iyC6D9R7o68nFKQP3c0zajDP9Ro9T0iCXQh-Dn3qwWoDsnM2gyJm96eKwjXnY6t5bV_tgJ-PscUiehqEMyPNkH8B3n0edQNJjflw9aHWX3ZPjflF9e_f269WHevXp_fLqclUbKvlYU0Iltoi3hhHIuBNMGgKJ4JhiCRHRaO2MhUYT3PBGlBdzuzZaWy3WopW4uaiWB10b9U4Nyfc67VXUXt0UYtoonUZvOqc0t0KSNZGQMiLLYMukM8JKbDSlEhWt1wetYVr3zhoXiindiejpTfBbtYk_lKSioYQVgRdHgRSL03lUvc_GdZ0Os-0Kc8wkRpLBgj7_B93FKYViVaEaKEo4IP5LbXR5gA9tnP9tFlWXHDcNJxTN1OI_VFnW9d7E4Fpf6icNL08aCjOWSGz0lLNafvl8yuIDa1LMObn21g8E1RxhdYiwKhFWNxFW-9L07K6Tty1_Mtv8Bqpr7Ww</recordid><startdate>20221019</startdate><enddate>20221019</enddate><creator>Joshua, Parker Elijah</creator><creator>Yahaya, Junaidu</creator><creator>Ekpo, Daniel Emmanuel</creator><creator>Ogidigo, Joyce Oloaigbe</creator><creator>Odiba, Arome Solomon</creator><creator>Asomadu, Rita Onyekachukwu</creator><creator>Oka, Samson Ayodeji</creator><creator>Adeniyi, Olasupo Stephen</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2424-1488</orcidid><orcidid>https://orcid.org/0000-0002-1837-0312</orcidid><orcidid>https://orcid.org/0000-0002-4269-1562</orcidid><orcidid>https://orcid.org/0000-0003-3323-0657</orcidid><orcidid>https://orcid.org/0000-0001-5648-441X</orcidid><orcidid>https://orcid.org/0000-0001-9201-8811</orcidid></search><sort><creationdate>20221019</creationdate><title>Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats</title><author>Joshua, Parker Elijah ; Yahaya, Junaidu ; Ekpo, Daniel Emmanuel ; Ogidigo, Joyce Oloaigbe ; Odiba, Arome Solomon ; Asomadu, Rita Onyekachukwu ; Oka, Samson Ayodeji ; Adeniyi, Olasupo Stephen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c597t-54592d17fc64067e869c404872529014a1becd0ca4237382617dbcaada8b8f923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>3-Carene</topic><topic>Acids</topic><topic>Animals</topic><topic>Antigens</topic><topic>Antioxidants</topic><topic>Antioxidants - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>BMC immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joshua, Parker Elijah</au><au>Yahaya, Junaidu</au><au>Ekpo, Daniel Emmanuel</au><au>Ogidigo, Joyce Oloaigbe</au><au>Odiba, Arome Solomon</au><au>Asomadu, Rita Onyekachukwu</au><au>Oka, Samson Ayodeji</au><au>Adeniyi, Olasupo Stephen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats</atitle><jtitle>BMC immunology</jtitle><addtitle>BMC Immunol</addtitle><date>2022-10-19</date><risdate>2022</risdate><volume>23</volume><issue>1</issue><spage>50</spage><epage>19</epage><pages>50-19</pages><artnum>50</artnum><issn>1471-2172</issn><eissn>1471-2172</eissn><abstract>Datura stramonium L. (Solanaceae) is used traditionally in west Africa to treat asthma, epilepsy, rheumatoid arthritis, filariasis microbial infections and conjunctivitis. This study investigated the immunomodulatory effects of aqueous seed extract of D. stramonium L. (ASEDS) on Wistar rats.
Thirty Wistar albino rats (180-200 g) were randomized into 6 groups (n = 5). Group 1 received distilled water only. Rats in groups 2-6 were pretreated with 10 mg/kg body weight (b.w.) Cyclophosphamide orally for 27-days to induce immunosuppression. Thereafter, they received treatment orally for 28 days as follows: Group 2 (distilled water), group 3 (5 mg/kg b.w. Levamisole), groups 4-6 (60, 90 and 120 mg/kg b.w. ASEDS, respectively). HPLC was used to determine major compounds in ASEDS. The effects of ASEDS on immune cells, immunoglobulins A, G and M levels, lipoproteins, and antioxidant status of rats were evaluated.
ASEDS indicated high content of Acutumine, Quinine, Catechin, Chlorogenic acid, Gallic acid, Quercetin, Vanillic acid, Luteolin, Formosanin C, Saponin, Cyanidin, Tannic acid, 3-Carene, Limonene and α-terpineol. Cyclophosphamide triggered significant (p < 0.05) reduction in total leucocyte count and differentials, IgA, IgG, high-density lipoproteins (HDL), catalase, superoxide dismutase, glutathione peroxidase, vitamins A, C and E levels of untreated rats. Administration of ASEDS led to significant (p < 0.05) improvement in immune cell counts, immunoglobulin synthesis, high-density lipoprotein concentration, and antioxidant status of rats in the treated groups.
The results obtained from the study showed the immunomodulatory activity of ASEDS, thereby indicating its potential in immunostimulatory drug discovery.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>36261807</pmid><doi>10.1186/s12865-022-00519-y</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0002-2424-1488</orcidid><orcidid>https://orcid.org/0000-0002-1837-0312</orcidid><orcidid>https://orcid.org/0000-0002-4269-1562</orcidid><orcidid>https://orcid.org/0000-0003-3323-0657</orcidid><orcidid>https://orcid.org/0000-0001-5648-441X</orcidid><orcidid>https://orcid.org/0000-0001-9201-8811</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1471-2172 |
| ispartof | BMC immunology, 2022-10, Vol.23 (1), p.50-19, Article 50 |
| issn | 1471-2172 1471-2172 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_a7d894b4905649459d69ec8d92ca5591 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | 3-Carene Acids Animals Antigens Antioxidants Antioxidants - pharmacology Asthma Body weight Catalase Catechin Chemical properties Chlorogenic Acid Complications and side effects Conjunctivitis Cyclophosphamide Cytokines Datura stramonium Datura stramonium L Drug dosages Enzymes Epilepsy Filariasis Flavonoids Gallic acid Gallic Acid - pharmacology Glutathione Peroxidase Health aspects Immune response Immune system Immunoglobulin A Immunoglobulin G Immunoglobulins Immunological research Immunomodulation Immunostimulation Immunosuppression Immunosuppression Therapy Jimson weed Levamisole Limonene Lipoproteins Lipoproteins, HDL Luteolin Materia medica, Vegetable Medicinal plants Phytochemicals Plant extracts Plant Extracts - pharmacology Quercetin Quinine Rats Rats, Wistar Rheumatoid arthritis Rodents Saponins Seeds Superoxide Dismutase Tannins Tumor necrosis factor-TNF Vanillic Acid Vitamins Water |
| title | Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T18%3A22%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Modulation%20of%20immunological%20responses%20by%20aqueous%20extract%20of%20Datura%20stramonium%20L.%20seeds%20on%20cyclophosphamide-induced%20immunosuppression%20in%20Wistar%20rats&rft.jtitle=BMC%20immunology&rft.au=Joshua,%20Parker%20Elijah&rft.date=2022-10-19&rft.volume=23&rft.issue=1&rft.spage=50&rft.epage=19&rft.pages=50-19&rft.artnum=50&rft.issn=1471-2172&rft.eissn=1471-2172&rft_id=info:doi/10.1186/s12865-022-00519-y&rft_dat=%3Cgale_doaj_%3EA723374512%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c597t-54592d17fc64067e869c404872529014a1becd0ca4237382617dbcaada8b8f923%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2730811802&rft_id=info:pmid/36261807&rft_galeid=A723374512&rfr_iscdi=true |