The Impact of Abnormal Glucose Tolerance and Obesity on Fetal Growth

Objective. Factors linked with insulin resistance were examined for their association with large-for-gestational-age (LGA) infant birth weight and gestational diabetes. Study Design. Data came from a longitudinal cohort study of 2,305 subjects without overt diabetes, analyzed using multinomial logis...

Full description

Saved in:
Bibliographic Details
Published in:Journal of diabetes research 2015-01, Vol.2015 (2015), p.1-10
Main Authors: Campbell, M. Karen, Yama, Brie, Van Aarsen, Kristine, Evers, Susan, Hill, David J., Graves, Erin, Yuan, Su
Format: Article
Language:English
Subjects:
Adult
Babies
Birth Weight
Body Mass Index
Carbohydrates
Diabetes, Gestational - metabolism
Diet
Fatty acids
Female
Fetal Development - physiology
Fetuses
Gestational Age
Gestational diabetes
Glucose
Glucose Intolerance - complications
Glucose Intolerance - metabolism
Health risk assessment
Hospitals
Humans
Infant
Infant, Newborn
Insulin resistance
Longitudinal Studies
Metabolism
Newborn babies
Nutrition research
Obesity
Obesity - complications
Obesity - metabolism
Population
Pregnancy
Secondary schools
Statistical analysis
Variables
Vitamin D
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective. Factors linked with insulin resistance were examined for their association with large-for-gestational-age (LGA) infant birth weight and gestational diabetes. Study Design. Data came from a longitudinal cohort study of 2,305 subjects without overt diabetes, analyzed using multinomial logistic and linear regression. Results. High maternal BMI ( OR = 1.53 (1.11, 2.12)), height (1.98 (1.62, 2.42)), antidepressant use (1.71 (1.20, 2.44)), pregnancy weight-gain exceeding 40 pounds (1.79 (1.25, 2.57)), and high blood sugar (2.68, (1.53, 5.27)) were all positively associated with LGA birth. Strikingly, the difference in risk from diagnosed and treated gestational diabetes compared to women with a single abnormal glucose tolerance test (but no diagnosis of gestational diabetes) was significant ( OR = 0.65 , p = 0.12 versus OR = 2.84 , p < 0.01 ). When weight/length ratio was used instead, different factors were found to be significant. BMI and pregnancy weight-gain were found to influence the development of gestational diabetes, through an additive interaction. Conclusions. High prepregnancy BM, height, antidepressant use, pregnancy weight-gain exceeding 40 pounds, and high blood sugar were associated with LGA birth, but not necessarily infant weight/length ratio. An additive interaction between BMI and pregnancy weight-gain influenced gestational diabetes development.
ISSN:2314-6745
2314-6753
DOI:10.1155/2015/847674