Structural basis of neuropeptide Y signaling through Y1 receptor

Neuropeptide Y (NPY) is highly abundant in the brain and involved in various physiological processes related to food intake and anxiety, as well as human diseases such as obesity and cancer. However, the molecular details of the interactions between NPY and its receptors are poorly understood. Here,...

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Bibliographic Details
Published in:	Nature communications 2022-02, Vol.13 (1), p.853-12, Article 853
Main Authors:	Park, Chaehee, Kim, Jinuk, Ko, Seung-Bum, Choi, Yeol Kyo, Jeong, Hyeongseop, Woo, Hyeonuk, Kang, Hyunook, Bang, Injin, Kim, Sang Ah, Yoon, Tae-Young, Seok, Chaok, Im, Wonpil, Choi, Hee-Jung
Format:	Article
Language:	English
Subjects:	101/28 14 14/19 631/45/612/194 631/45/882 631/535/1258/1259 82/83 96 96/95 Animals Anxiety Binding Brain - metabolism Cell Line Cryoelectron Microscopy Electron microscopy Enzyme Activation - physiology Food Food intake Food processing Humanities and Social Sciences Humans multidisciplinary Mutagenesis Neuropeptide Y Neuropeptide Y - genetics Neuropeptide Y - metabolism Neuropeptides Protein Binding - physiology Protein Conformation Proteins Receptors Receptors, Neuropeptide Y - genetics Receptors, Neuropeptide Y - metabolism Residues Science Science (multidisciplinary) Sf9 Cells Signal Transduction Stress response Structural analysis
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