Innate Immunity of the Lung

Infections with respiratory viruses such as influenza, rhinovirus, and respiratory syncytial virus are an important problem in the general population, as well as in subjects with chronic lung diseases such as asthma and chronic obstructive pulmonary disease (COPD), whereas infection with corona viru...

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Bibliographic Details
Published in:Journal of Innate Immunity 2020-01, Vol.12 (1), p.1-3
Main Authors: Greene, Catherine M., Hiemstra, Pieter S.
Format: Article
Language:English
Subjects:
Animals
Editorial
Humans
Immune Evasion
Immunity, Innate - immunology
Lung - immunology
Respiratory Tract Infections - immunology
Virus Diseases - immunology
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Summary:Infections with respiratory viruses such as influenza, rhinovirus, and respiratory syncytial virus are an important problem in the general population, as well as in subjects with chronic lung diseases such as asthma and chronic obstructive pulmonary disease (COPD), whereas infection with corona viruses (CoVs) such as SARS-CoV and MERS-CoV, and bird flu-causing avian influenza have made the headlines in the media in recent years. Next, insight is provided into their role in immunity and lung diseases such as asthma, COPD, lung fibrosis, and cystic fibrosis, based on lessons learned from animal models and human studies. In addition to macrophages and other lung cells, the airway epithelial cells that line the airway lumen also use a range of TLRs to monitor microbial presence at the epithelial surface, and this may lead to an enhanced production of antimicrobial peptides (AMPs) that serve as effector molecules of innate immunity by killing micro-organisms, modulating immunity, and enhancing wound repair. [...]the study by Yue et al.
ISSN:1662-811X
1662-8128
DOI:10.1159/000504621