Evolution and bad prognostic value of advanced glycation end products after acute heart failure: relation with body composition

• Published in: Cardiovascular diabetology 2017-09, Vol.16 (1), p.115-115, Article 115
• Main Authors: Paradela-Dobarro, Beatriz, Fernández-Trasancos, Ángel, Bou-Teen, Diana, Eiras, Sonia, González-Ferreiro, Rocío, Agra, Rosa M, Varela-Román, Alfonso, Castro-Pais, Ana I, Carreira, Marcos C, Casanueva, Felipe F, Álvarez, Ezequiel, González-Juanatey, José R
• Format: Article
• Language: English
• Subjects: Acute coronary syndromes; Acute Disease; Acute heart failure; Advanced glycation end products; Advanced glycosylation end products; Aged; Aged, 80 and over; Bioindicators; Biomarkers; Body composition; Body Composition - physiology; Body fat; Body mass; Body mass index; Cardiovascular disease; Cholesterol; Chronic illnesses; Death; Diabetes; Dual energy X-ray absorptiometry; Echocardiography; EKG; Family medical history; Female; Follow-Up Studies; Glycation End Products, Advanced - blood; Glycosylation; Heart diseases; Heart failure; Heart Failure - blood; Heart Failure - diagnostic imaging; Heart Failure - mortality; Heart failure prognosis; Heart failure progression; Humans; Inflammation; Male; Malnutrition; Metabolic syndrome; Middle Aged; Nutritional status; Obesity; Original Investigation; Oxidative stress; Patients; Peripheral blood; Prognosis; Prospective Studies; Receptor for Advanced Glycation End Products - blood; Regression analysis; Renal function; Risk Factors; Soluble RAGE; Studies; Weight control
• ISSN: 1475-2840; 1475-2840
• DOI: 10.1186/s12933-017-0598-3

The role of advanced glycation end products (AGEs) and their soluble receptor (sRAGE) on the progression and prognosis of acute heart failure (HF) was analysed in relation with metabolic parameters as body composition and nutritional status. A hundred and fifty consecutive patients were included in a prospective clinical study during hospitalization by acute HF. Detailed medical history, physical examination, electrocardiogram, echocardiogram and vein peripheral blood were taken for all patients. During the follow-up period [297 days (88-422 days)] blood samples for biochemical measurements were obtained 1 and 6 months after the inclusion. Dual-energy X-ray absorptiometry analyses were performed 1 week after discharge. AGEs and sRAGE levels continuously increased, up to 6 months, after acute HF, but AGEs increase was mainly observed in those patients with incident HF. Both AGEs and sRAGE levels were related with bad renal function and clinical malnutrition (CONUT score) and they were negatively related with body mass index or percentage of body fat. AGEs levels (≥40 a.u.) 1 month after discharge and basal sRAGE levels (>1000 pg/mL) were related with worse prognosis in terms of patient death and HF readmission (Log-rank