Significant Relationship Between Serum High-sensitivity C-Reactive Protein, High-density Lipoprotein Cholesterol Levels and Children With Kawasaki Disease and Coronary Artery Lesions

Background/Purpose The aim of this study was to understand the association between Kawasaki disease (KD) in children and serum high-sensitivity C-reactive protein (hs-CRP), which is a sensitive indicator of inflammation, lipid profiles and coronary artery lesions. Methods Between July 2005 and Decem...

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Published in:Journal of the Formosan Medical Association 2009-09, Vol.108 (9), p.719-724
Main Authors: Ou, Chun-Yen, Tseng, Yu-Fang, Lee, Cheng-Liang, Chiou, Yee-Hsuan, Hsieh, Kai-Sheng
Format: Article
Language:English
Subjects:
Adolescent
C-reactive protein
C-Reactive Protein - analysis
Child
Child, Preschool
cholesterol HDL
Cholesterol, HDL - blood
coronary artery disease
Coronary Artery Disease - blood
Female
Humans
Infant
Internal Medicine
Kawasaki disease
Male
Mucocutaneous Lymph Node Syndrome - blood
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Summary:Background/Purpose The aim of this study was to understand the association between Kawasaki disease (KD) in children and serum high-sensitivity C-reactive protein (hs-CRP), which is a sensitive indicator of inflammation, lipid profiles and coronary artery lesions. Methods Between July 2005 and December 2007, 119 children with KD at least 1 year after diagnosis were recruited. The children were classified into one of two groups: Group I comprised 55 children with KD and coronary aneurysms; Group 2 comprised 64 children with KD and normal coronary arteries. The relationship between hs-CRP concentration and high-density lipoprotein cholesterol (HDL-C) and the size of arterial lesions was investigated in Group I 1 year after onset of KD. Results Serum hs-CRP levels in Group I (mean, 0.251mg/dL) were significantly greater than those in Group II (mean, 0.162mg/dL; p = 0.011). However, plasma HDL-C levels in Group I (mean 42.51 mg/dL) were significantly lower than those in Group II (mean, 44.34 mg/dL; p = 0.037). In Group I, there was a positive association between hs-CRP and the size of coronary artery lesions ( r = 0.672, p = 0.035), but no association between lipid profiles, including HDL-C, and coronary artery lesions (all p > 0.05). Conclusion Our results support the possibility of ongoing low-grade inflammation late after the acute phase of KD in children with coronary aneurysms. Serum hs-CRP and HDL-C levels are associated with coronary artery lesions in children with KD.
ISSN:0929-6646
DOI:10.1016/S0929-6646(09)60395-8