The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial

Despite primary vaccination, infants under six months run a risk of infection with pertussis. To determine the impact of early postpartum maternal pertussis vaccination on protecting infants from the disease. All mothers (n=405) who gave birth to healthy term infants were educated on the cocoon stra...

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Bibliographic Details
Published in:Iranian journal of immunology 2019-09, Vol.16 (3), p.225-234
Main Authors: Kılıç, Ayşe, Yener, Gülçin Otar, Yetim, Aylin, Özçetin, Mustafa, Gökçay, Gülbin, Çoban, Asuman, Ince, Zeynep, Yaşa, Beril, Öksüz, Lütfiye, Uğurlucan, Funda Güngör, Gürler, Nezahat
Format: Article
Language:English
Subjects:
Adult
Antibodies, Bacterial - blood
Bordetella pertussis - immunology
Diphtheria
Diphtheria-Tetanus-acellular Pertussis Vaccines - immunology
Female
Humans
Immunity, Maternally-Acquired
Immunization
Immunoglobulin G
Immunoglobulin G - blood
Infant
Infant, Newborn
Infants
Maternal Exposure
Maternal Immunization
Pertussis
Pertussis Vaccine
Postpartum
Postpartum Period
Socioeconomic Factors
Tetanus
Vaccination
Vaccines
Whooping cough
Whooping Cough - immunology
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Summary:Despite primary vaccination, infants under six months run a risk of infection with pertussis. To determine the impact of early postpartum maternal pertussis vaccination on protecting infants from the disease. All mothers (n=405) who gave birth to healthy term infants were educated on the cocoon strategy. The mothers who consented were immunized with the tetanus-diphtheria-acellular pertussis vaccine within the first three postpartum days. All infants received their pertussis vaccines according to the national schedule. The anti-pertussis IgG titers of infants of thirty vaccinated mothers were compared with those of thirty unvaccinated mothers. The pertussis antibody levels in the infants of vaccinated mothers were significantly higher than those of unvaccinated mothers at the mean infant age of 5.6 ± 1.2 months. Only 6 infants of vaccinated mothers exhibited pertussis-like symptoms, none of whom had positive pertussis PCR. Seventeen infants of unvaccinated mothers had pertussis-like symptoms, and 4 tested positive for pertussis PCR. Our results showed that maternal pertussis vaccination, administered within the first three postpartum days, may protect infants against pertussis in their first ten months.
ISSN:1735-1383
1735-367X
DOI:10.22034/iji.2019.80273