A Novel Vaccine Delivery Model of the Apicomplexan Eimeria tenella Expressing Eimeria maxima Antigen Protects Chickens against Infection of the Two Parasites

Vaccine delivery is critical in antigen discovery and vaccine efficacy and safety. The diversity of infectious diseases in humans and livestock has required the development of varied delivery vehicles to target different pathogens. In livestock animals, previous strategies for the development of coc...

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Bibliographic Details
Published in:Frontiers in immunology 2018-01, Vol.8, p.1982-1982
Main Authors: Tang, Xinming, Liu, Xianyong, Yin, Guangwen, Suo, Jingxia, Tao, Geru, Zhang, Sixin, Suo, Xun
Format: Article
Language:English
Subjects:
Eimeria maxima
immune mapped protein 1
Immunology
protective immunity
transgenic Eimeria
vaccine delivery model
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Summary:Vaccine delivery is critical in antigen discovery and vaccine efficacy and safety. The diversity of infectious diseases in humans and livestock has required the development of varied delivery vehicles to target different pathogens. In livestock animals, previous strategies for the development of coccidiosis vaccines have encountered several hurdles, limiting the development of multiple species vaccine formulations. Here, we describe a novel vaccine delivery system using transgenic expressing immunodominant antigens of . In this delivery system, the immune mapped protein 1 of (EmIMP1) was delivered by the closely related species of to the host immune system during the whole endogenous life cycle. The overexpression of the exogenous antigen did not interfere with the reproduction and immunogenicity of transgenic . After immunization with the transgenic parasite, we detected EmIMP1's and oocyst antigens' specific humoral and cellular immune responses. In particular, we observed partial protection of chickens immunized with transgenic against subsequent infections. Our results demonstrate that the transgenic parasite is an ideal coccidia antigen delivery vehicle and represents a new type of coccidiosis vaccines. In addition, this model could potentially be used in the development of malaria live sporozoite vaccines, in which antigens from different strains can be expressed in the vaccine strain.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2017.01982