The clinical efficacy of single-hole punch excision combined with intralesional steroid injection for nodular keloid treatment: a self-controlled trial

• Published in: Scientific reports 2024-04, Vol.14 (1), p.9793-9793, Article 9793
• Main Authors: Liu, Bingbing, Lin, Haoying, Zhang, Minghai
• Format: Article
• Language: English
• Subjects: 692/308; 692/699; Adolescent; Adult; Combined Modality Therapy; Female; Humanities and Social Sciences; Humans; Injection; Injections, Intralesional - methods; Intralesional injection; Keloid - drug therapy; Keloid - surgery; Keloid - therapy; Lesions; Male; Middle Aged; multidisciplinary; Nodular keloid; Punch excision; Radiation therapy; Science; Science (multidisciplinary); Side effects; Single-hole; Skin diseases; Skin lesions; Statistical analysis; Steroid; Steroids; Steroids - administration & dosage; Symmetry; Treatment Outcome; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-60670-x

There are many methods to treat keloid, including various excision operations, laser, injection and radiotherapy. However, few studies have explored the effectiveness of single-hole punch excision in keloid treatment. This study aimed to investigate the efficacy and safety of lateral punch excision combined with intralesional steroid injection for keloid treatment through self-control trial. In this self-controlled trial, 50 patients meet the diagnosis of nodular keloid, and try to choose left–right symmetrical control, one skin lesion in the control group (50 skin lesionsin total) and the other in the observation group (50 skin lesions in total).The keloids in the treatment group were initially treated with punch excision combined with intralesional steroid injection, followed by injection treatment alone. Keloids in the control group received intralesional steroid injection alone. The Vancouver Scar Scale (VSS) of the keloid before and after the punch excision was evaluated; the keloid scores at different time points and the number of injection treatments required in both groups were compared, and adverse reactions were observed. The effective rate of the observation group was 86.0%, which was significantly higher than that of the control group (66.0%), and the recurrence rate of 22% was lower than that of the control group (χ 2  = 4.141,63417), all of which were statistically significant (all P