IGF1 for the diagnosis of growth hormone deficiency in children and adolescents: a reappraisal

A number of studies have evaluated the role of IGF1 measurement in the diagnosis of growth hormone deficiency (GHD). This study aimed to evaluate the accuracy and the best cut-off of IGF1 SDS in the diagnosis of GHD in a large cohort of short children and adolescents. One-hundred and forty-two child...

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Published in:Endocrine Connections 2020-11, Vol.9 (11), p.1095-1102
Main Authors: Ibba, Anastasia, Corrias, Francesca, Guzzetti, Chiara, Casula, Letizia, Salerno, Mariacarolina, di Iorgi, Natascia, Tornese, Gianluca, Patti, Giuseppa, Radetti, Giorgio, Maghnie, Mohamad, Cappa, Marco, Loche, Sandro
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Language:English
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adolescents
children
growth hormone deficiency
insulin-like growth factor 1
short stature
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container_end_page 1102
container_issue 11
container_start_page 1095
container_title Endocrine Connections
container_volume 9
creator Ibba, Anastasia
Corrias, Francesca
Guzzetti, Chiara
Casula, Letizia
Salerno, Mariacarolina
di Iorgi, Natascia
Tornese, Gianluca
Patti, Giuseppa
Radetti, Giorgio
Maghnie, Mohamad
Cappa, Marco
Loche, Sandro
description A number of studies have evaluated the role of IGF1 measurement in the diagnosis of growth hormone deficiency (GHD). This study aimed to evaluate the accuracy and the best cut-off of IGF1 SDS in the diagnosis of GHD in a large cohort of short children and adolescents. One-hundred and forty-two children and adolescents with GHD ((63 organic/genetic (OGHD), 79 idiopathic (IGHD)) and 658 short non-GHD children (median age 10.4 years) were included in the analysis. The two groups were subdivided according to age (G1
doi_str_mv 10.1530/EC-20-0347
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This study aimed to evaluate the accuracy and the best cut-off of IGF1 SDS in the diagnosis of GHD in a large cohort of short children and adolescents. One-hundred and forty-two children and adolescents with GHD ((63 organic/genetic (OGHD), 79 idiopathic (IGHD)) and 658 short non-GHD children (median age 10.4 years) were included in the analysis. The two groups were subdivided according to age (G1 &lt;6, G2 6 &lt;9, G3 9 &lt;12, G4 ≥12) and to pubertal status. Serum IGFI was measured by the same chemiluminescence assay in all samples and expressed as age- and sex-based SDS. Receiver operating characteristic (ROC) analysis was used to evaluate the optimal IGF1 SDS cut-off and the diagnostic accuracy. Median IGF1 SDS was significantly lower in the GHD than in non-GHD patients. The area under the curve (AUC) was 0.69, with the best IGF1 cut-off of −1.5 SDS (sensitivity 67.61%, specificity 62.62%). The AUC was 0.75 for OGHD and 0.63 for IGHD. 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subjects adolescents
children
growth hormone deficiency
insulin-like growth factor 1
short stature
title IGF1 for the diagnosis of growth hormone deficiency in children and adolescents: a reappraisal
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