Efficacy and safety of cardiac resynchronization therapy in chemotherapy‐induced cardiomyopathy: A systematic review

Objective The aim of the study was to assess the efficacy of cardiac resynchronization therapy (CRT) in patients with chemotherapy‐induced cardiomyopathy (CIC). Methods With the increasing incidence of CIC, the association of CRT with improvement in clinical outcomes, echocardiographic parameters, a...

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Published in:Annals of noninvasive electrocardiology 2023-09, Vol.28 (5), p.e13070-n/a
Main Authors: Shehram, Muhammad, Khalid, Hiba, Shafique, Hafiz Muhammad, Umer, Bakht, Zafar, Awais, Ullah, Asif, Zaidi, Syed Muhammad Jawad, Basit, Jawad, Mehmoodi, Amin, Malik, Jahanzeb
Format: Article
Language:English
Subjects:
anthracycline
Breast cancer
Cancer therapies
Cardiomyopathy
Chemotherapy
Clinical trials
Demographics
diastolic dysfunction
Effectiveness
ejection fraction
Heart
Heart failure
Leukemia
Lymphoma
Mortality
Observational studies
Parameters
Patients
Quality of life
Review
Sarcoma
Systematic review
Ventricle
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Summary:Objective The aim of the study was to assess the efficacy of cardiac resynchronization therapy (CRT) in patients with chemotherapy‐induced cardiomyopathy (CIC). Methods With the increasing incidence of CIC, the association of CRT with improvement in clinical outcomes, echocardiographic parameters, and New York Heart Classification (NYHA) class was assessed through this qualitative systematic review. Results The five studies included a total of 169 patients who underwent CRT after CIC, and of these, 61 (36.1%) patients were males. All studies showed an improvement in left ventricular ejection fraction (LVEF), among other echocardiographic parameters of LV volume. However, these findings are limited by short follow‐up periods, small sample sizes, and the absence of a control group. Conclusion CRT was associated with improvement in all patient parameters with CIC. The five studies included a total of 169 patients who underwent CRT after CIC, which showed an improvement in left ventricular ejection fraction (LVEF), among other echocardiographic parameters of LV volume. However, these findings are limited by short follow‐up periods, small sample sizes, and the absence of a control group.
ISSN:1082-720X
1542-474X
DOI:10.1111/anec.13070