NMR-Based Plasma Metabolomics at Set Intervals in Newborn Dairy Calves with Severe Sepsis

The aim of this first study was to reveal the new potential biomarkers by a metabolomics approach in severe septic calves. Sepsis is a common cause of morbidity and mortality in newborn dairy calves. The main challenges with the use of biomarkers of sepsis in domestic animals are their availability,...

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Bibliographic Details
Published in:Mediators of inflammation 2018-01, Vol.2018 (2018), p.1-12
Main Authors: Tenori, Leonardo, Meoni, Gaia, Sen, Ismail, Basoglu, Abdullah, Naseri, Amir
Format: Article
Language:English
Subjects:
Amino acids
Analytical chemistry
Biomarkers
Blood
Cattle
Diarrhea
Domestic animals
Handbooks
Health aspects
Infants (Newborn)
Infection
Infections
Laboratories
Metabolism
Metabolites
Metabolomics
Molecular weight
Morbidity
Mortality
Multivariate analysis
Neonates
NMR
Nuclear magnetic resonance
Sepsis
Teaching hospitals
Urine
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Summary:The aim of this first study was to reveal the new potential biomarkers by a metabolomics approach in severe septic calves. Sepsis is a common cause of morbidity and mortality in newborn dairy calves. The main challenges with the use of biomarkers of sepsis in domestic animals are their availability, cost, and time required to obtain a result. Metabolomics may offer the potential to identify biomarkers that define calf sepsis in terms of combined clinical, physiological, and pathobiological abnormalities. To our knowledge, this is the first study presenting an NMR- (nuclear magnetic resonance-) based plasma metabolomics at set intervals in neonatal septic calves. Twenty neonatal dairy calves with severe sepsis and ten healthy calves were used. Hematological and biochemical health profiles were gathered in plasma samples at set intervals. Similarly, NMR spectra were acquired. All diseased animals (except one) died after 72 hours. Clinical and laboratory results were in accordance with those of severe septic animals. Multivariate analysis on NMR plasma spectra proved to be an excellent tool for faster identification of calves with severe sepsis from healthy animals. The NMR-based metabolomic profile may contribute to the better understanding of severe sepsis in newborn calves.
ISSN:0962-9351
1466-1861
DOI:10.1155/2018/8016510