The Hippocampal Barque: An Epileptiform but Non-epileptic Hippocampal Entity

All samples were derived from an electrode contact implanted in non-epileptic hippocampal tissue in patients with extra-temporal focal epilepsy in which either hippocampus was not part of the seizure onset zone, either on the right or left hippocampus. Despite the fact that barques manifest as train...

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Bibliographic Details
Published in:Frontiers in human neuroscience 2020-03, Vol.14, p.92-92
Main Authors: Kokkinos, Vasileios, Richardson, Robert Mark, Urban, Alexandra
Format: Article
Language:English
Subjects:
14&6/s positive spikes
Conflicts of interest
Convulsions & seizures
Dictionaries
Electrodes
Electroencephalography
Epilepsy
epilepsy surgery
Firing pattern
Hippocampus
Human Neuroscience
Morphology
Neurosurgery
Patients
SEEG
Seizures
Sleep
Surgery
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Summary:All samples were derived from an electrode contact implanted in non-epileptic hippocampal tissue in patients with extra-temporal focal epilepsy in which either hippocampus was not part of the seizure onset zone, either on the right or left hippocampus. Despite the fact that barques manifest as trains of high-voltage negative-phase spikes, thereby resembling epileptiform discharges, evidence derived from non-epileptic hippocampal tissue in patients with extra-temporal focal epilepsy, where it was shown that the hippocampus was not part of the seizure onset zone, show that they are not epileptic (Kokkinos et al., 2019). [...]we recommend that hippocampal barques should not be considered as markers of epileptogenicity in mesial-temporal intracranial investigations for epilepsy surgery, as well as in responsive neurostimulation (RNS) post-implantation evaluations (Figure 1D). J. Pediatr. 72, 678–682. doi: 10.1016/S0022-3476(68)80012-5 Vasileios Kokkinos1,2*, Robert Mark Richardson1,2 and Alexandra Urban3,4 * 1Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, United States * 2Harvard Medical School, Boston, MA, United States * 3Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States * 4University of Pittsburgh Comprehensive Epilepsy Center, Pittsburgh, PA, United States
ISSN:1662-5161
1662-5161
DOI:10.3389/fnhum.2020.00092