In Vitro Antioxidant, Antityrosinase, and Cytotoxic Activities of Astaxanthin from Shrimp Waste

Astaxanthin is a potent antioxidant compared with vitamins and other antioxidants. However, astaxanthin extract from shrimp processing waste has not yet been used in cosmetic products. This study aimed to explore the natural astaxanthin from shrimp shells for antioxidant and antityrosinase activitie...

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Bibliographic Details
Published in:Antioxidants 2019-05, Vol.8 (5), p.128
Main Authors: Chintong, Sutasinee, Phatvej, Wipaporn, Rerk-Am, Ubon, Waiprib, Yaowapha, Klaypradit, Wanwimol
Format: Article
Language:English
Subjects:
Acids
antioxidant property
Antioxidants
Astaxanthin
Bleaching
Cytotoxicity
Dietary supplements
Ethanol
Laboratories
Oxygen
shrimp astaxanthin
Skin cancer
Sulfonic acid
tyrosinase inhibition
Vitamins
β-Carotene
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Summary:Astaxanthin is a potent antioxidant compared with vitamins and other antioxidants. However, astaxanthin extract from shrimp processing waste has not yet been used in cosmetic products. This study aimed to explore the natural astaxanthin from shrimp shells for antioxidant and antityrosinase activities as well as potential toxicity. The antioxidant activities were performed with 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging, β-carotene bleaching, and singlet oxygen quenching assays. The results revealed that astaxanthin extract demonstrated potent antioxidant activities against DPPH and ABTS radicals, and prevented the bleaching of β-carotene and quenching of singlet oxygen (EC 17.5 ± 3.6, 7.7 ± 0.6, 15.1 ± 1.9 and 9.2 ± 0.5 μg/mL, respectively). Furthermore, the astaxanthin extract could inhibit tyrosinase activity (IC 12.2 ± 1.5 μg/mL) and had no toxic effects on human dermal fibroblast cells. These results suggested that shrimp astaxanthin would be a promising dietary supplement for skin health applications.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox8050128