Functional Disconnection of the Angular Gyrus Related to Cognitive Impairment in Patients With Type 2 Diabetes Mellitus

Type 2 diabetes mellitus (T2DM) is related to a variety of cognitive impairments that may even progress to dementia. Studies have found the angular gyrus (AG) is a cross-modal integration hub that is involved in a variety of cognitive processes. However, few studies have focused on the patterns of r...

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Bibliographic Details
Published in:Frontiers in human neuroscience 2021-02, Vol.15, p.621080-621080
Main Authors: Qi, Fei, Zhang, Dongsheng, Gao, Jie, Tang, Min, Wang, Man, Su, Yu, Lei, Yumeng, Shao, Zhirong, Zhang, Xiaoling
Format: Article
Language:English
Subjects:
angular gyrus
Brain
Brain mapping
Cognition & reasoning
Cognitive ability
Dementia
Dementia disorders
Diabetes
Diabetes mellitus (non-insulin dependent)
Disease
Executive function
Fasting
functional connectivity
Functional magnetic resonance imaging
Glucose
Insulin
Medical imaging
Memory
Metabolism
neuroimaging
Neuropathology
Neuroscience
Patients
resting-state fMRI
Sensory integration
Temporal lobe
type 2 diabetes mellitus
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Summary:Type 2 diabetes mellitus (T2DM) is related to a variety of cognitive impairments that may even progress to dementia. Studies have found the angular gyrus (AG) is a cross-modal integration hub that is involved in a variety of cognitive processes. However, few studies have focused on the patterns of resting-state functional connections (rsFCs) of the AG in patients with T2DM. This study explored the functional connection (FC) between the AG and the whole brain and the relationship between the FC and clinical/cognitive variables in patients with T2DM. 44 patients with T2DM and 43 sex-, age-, and education-matched healthy controls underwent resting-state fMRI and received neuropsychological assessments. Compared with the control group, the T2DM group showed abnormal rsFCs between the AG and multiple brain regions. The FC between the left AG and the left medial temporal lobe in the T2DM group was positively correlated with scores on the Montreal Cognitive Assessment, after a Bonferroni correction ( = 0.40, = 0.009). Collectively, patients with T2DM have abnormal FCs between the AG and extensive brain regions that may be related to various cognitive processes.
ISSN:1662-5161
1662-5161
DOI:10.3389/fnhum.2021.621080