Loading…
Association of healthy lifestyle score with all-cause mortality and life expectancy: a city-wide prospective cohort study of cancer survivors
Background Adherence to a healthy lifestyle could reduce the cancer mortality in the western population. We conducted a city-wide prospective study in China investigating the association of a healthy lifestyle score with all-cause mortality and the life expectancy in cancer survivors. Methods This p...
Saved in:
Published in: | BMC medicine 2021-07, Vol.19 (1), p.1-158, Article 158 |
---|---|
Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c571t-be3ab8243620e6b63aad0dbc39ed90b0208fb05001d3f846fe0c74a0a5617c7c3 |
---|---|
cites | cdi_FETCH-LOGICAL-c571t-be3ab8243620e6b63aad0dbc39ed90b0208fb05001d3f846fe0c74a0a5617c7c3 |
container_end_page | 158 |
container_issue | 1 |
container_start_page | 1 |
container_title | BMC medicine |
container_volume | 19 |
creator | Sun, Ce Li, Ke Xu, Huan Wang, Xiangjun Qin, Pengzhe Wang, Suixiang Liang, Boheng Xu, Lin |
description | Background Adherence to a healthy lifestyle could reduce the cancer mortality in the western population. We conducted a city-wide prospective study in China investigating the association of a healthy lifestyle score with all-cause mortality and the life expectancy in cancer survivors. Methods This prospective cohort study included 46,120 surviving patients who were firstly diagnosed with cancer in Guangzhou. Five low-risk lifestyle factors including never smoking, never alcohol use, regular physical activity ([greater than or equai to] 2 h/week), sufficient sleep ([greater than or equai to] 6 h/day), and normal or high BMI ([greater than or equai to] 18.5 kg/m.sup.2) were assessed and a lifestyle score (0-5, a higher score indicates healthier lifestyle) was generated. Hazard ratios (HRs) of all-cause mortality and the life expectancy by levels of the lifestyle scores were estimated. Results Of 46,120 cancer survivors registered from 2010 to 2017, during an average follow-up of 4.3 years (200,285 person-years), 15,209 deaths were recorded. Adjusted HRs for mortality in cancer survivors with lifestyle score of 0-2, versus 5, were 2.59 (95% confidence interval (CI): 2.03-3.30) in women, 1.91 (95%CI 1.77-2.05) in men, 2.28 (95%CI 2.03-2.55) in those aged |
doi_str_mv | 10.1186/s12916-021-02024-2 |
format | article |
fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_b2027fc070a845a3a714c13e926d3ca2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A672336561</galeid><doaj_id>oai_doaj_org_article_b2027fc070a845a3a714c13e926d3ca2</doaj_id><sourcerecordid>A672336561</sourcerecordid><originalsourceid>FETCH-LOGICAL-c571t-be3ab8243620e6b63aad0dbc39ed90b0208fb05001d3f846fe0c74a0a5617c7c3</originalsourceid><addsrcrecordid>eNptkt9qFDEUxgdRbK2-gFcBQbyZmj8zyYwXwlKqFgre6HU4kzmzmyU7WZPMtvMQvnOzu0W7IiEk5PzOF_LlK4q3jF4y1siPkfGWyZJyliflVcmfFedMVaxUlNXPn-zPilcxrinltVLVy-JMVJy3Usrz4vciRm8sJOtH4geyQnBpNRNnB4xpdkii8QHJnU0rAs6VBqaIZONDAmfTTGDsDzDB-y2aBKOZPxEgJtfKO9sj2QYf9xW7Q2L8KjeSmKZ-3t9mMo6BxCns7M6H-Lp4MYCL-OZxvSh-frn-cfWtvP3-9eZqcVuaWrFUdiiga3glJKcoOykAetp3RrTYt7TLZjRDR2tKWS-GppIDUqMqoFBLpowy4qK4Oer2HtZ6G-wGwqw9WH048GGpISRrHOouO6sGQxWFpqpBgGKVYQJbLnthgGetz0et7dRtsDc4pgDuRPS0MtqVXvqdbrhkrWiywIdHgeB_Tdl1vbHRoHMwop-i5nXVsrZtWpnRd_-gaz-FMVuVqZo3IgeC_6WWkB9gx8Hne81eVC-k4kLI7EOmLv9D5dHjxho_4mDz-UnD-ycNx6BE76Z9dOIpyI-gyV8fAw5_zGBU75Orj8nVObn6kFzNxQNgseBD</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2552832912</pqid></control><display><type>article</type><title>Association of healthy lifestyle score with all-cause mortality and life expectancy: a city-wide prospective cohort study of cancer survivors</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Sun, Ce ; Li, Ke ; Xu, Huan ; Wang, Xiangjun ; Qin, Pengzhe ; Wang, Suixiang ; Liang, Boheng ; Xu, Lin</creator><creatorcontrib>Sun, Ce ; Li, Ke ; Xu, Huan ; Wang, Xiangjun ; Qin, Pengzhe ; Wang, Suixiang ; Liang, Boheng ; Xu, Lin</creatorcontrib><description>Background Adherence to a healthy lifestyle could reduce the cancer mortality in the western population. We conducted a city-wide prospective study in China investigating the association of a healthy lifestyle score with all-cause mortality and the life expectancy in cancer survivors. Methods This prospective cohort study included 46,120 surviving patients who were firstly diagnosed with cancer in Guangzhou. Five low-risk lifestyle factors including never smoking, never alcohol use, regular physical activity ([greater than or equai to] 2 h/week), sufficient sleep ([greater than or equai to] 6 h/day), and normal or high BMI ([greater than or equai to] 18.5 kg/m.sup.2) were assessed and a lifestyle score (0-5, a higher score indicates healthier lifestyle) was generated. Hazard ratios (HRs) of all-cause mortality and the life expectancy by levels of the lifestyle scores were estimated. Results Of 46,120 cancer survivors registered from 2010 to 2017, during an average follow-up of 4.3 years (200,285 person-years), 15,209 deaths were recorded. Adjusted HRs for mortality in cancer survivors with lifestyle score of 0-2, versus 5, were 2.59 (95% confidence interval (CI): 2.03-3.30) in women, 1.91 (95%CI 1.77-2.05) in men, 2.28 (95%CI 2.03-2.55) in those aged <65 years, and 1.90 (95%CI 1.75, 2.05) in those aged [greater than or equai to] 65 years. Life expectancy at age 55 for those with a score of 0-2 and 5 was 53.4 and 57.1 months, respectively. We also found that cancer survivors with healthy lifestyle scores of 5 showed 59.9 months of life expectancy on average, which was longer than those with a score of 0-2. Conclusion Adopting a healthy lifestyle was associated with a substantially lower risk of all-cause mortality and longer life expectancy in cancer survivors. Our findings should be useful for health education and health promotion in primary care and clinical practice. Keywords: Healthy lifestyle, Cancer survivor, Mortality, Life expectancy</description><identifier>ISSN: 1741-7015</identifier><identifier>EISSN: 1741-7015</identifier><identifier>DOI: 10.1186/s12916-021-02024-2</identifier><identifier>PMID: 34229666</identifier><language>eng</language><publisher>London: BioMed Central Ltd</publisher><subject>Age groups ; Alcohol use ; Behavior ; Body mass index ; Cancer ; Cancer survivor ; Cancer survivors ; Cancer therapies ; Chemotherapy ; China ; Chinese medicine ; Cohort analysis ; Confidence intervals ; Health aspects ; Health behavior ; Health care ; Health promotion ; Healthy lifestyle ; Life expectancy ; Life span ; Life style ; Lifestyles ; Medical records ; Mortality ; Municipal finance ; Physical activity ; Radiation therapy ; Risk factors ; Sleep ; Smoking ; Statistical analysis ; Survival</subject><ispartof>BMC medicine, 2021-07, Vol.19 (1), p.1-158, Article 158</ispartof><rights>COPYRIGHT 2021 BioMed Central Ltd.</rights><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-be3ab8243620e6b63aad0dbc39ed90b0208fb05001d3f846fe0c74a0a5617c7c3</citedby><cites>FETCH-LOGICAL-c571t-be3ab8243620e6b63aad0dbc39ed90b0208fb05001d3f846fe0c74a0a5617c7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261938/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2552832912?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids></links><search><creatorcontrib>Sun, Ce</creatorcontrib><creatorcontrib>Li, Ke</creatorcontrib><creatorcontrib>Xu, Huan</creatorcontrib><creatorcontrib>Wang, Xiangjun</creatorcontrib><creatorcontrib>Qin, Pengzhe</creatorcontrib><creatorcontrib>Wang, Suixiang</creatorcontrib><creatorcontrib>Liang, Boheng</creatorcontrib><creatorcontrib>Xu, Lin</creatorcontrib><title>Association of healthy lifestyle score with all-cause mortality and life expectancy: a city-wide prospective cohort study of cancer survivors</title><title>BMC medicine</title><description>Background Adherence to a healthy lifestyle could reduce the cancer mortality in the western population. We conducted a city-wide prospective study in China investigating the association of a healthy lifestyle score with all-cause mortality and the life expectancy in cancer survivors. Methods This prospective cohort study included 46,120 surviving patients who were firstly diagnosed with cancer in Guangzhou. Five low-risk lifestyle factors including never smoking, never alcohol use, regular physical activity ([greater than or equai to] 2 h/week), sufficient sleep ([greater than or equai to] 6 h/day), and normal or high BMI ([greater than or equai to] 18.5 kg/m.sup.2) were assessed and a lifestyle score (0-5, a higher score indicates healthier lifestyle) was generated. Hazard ratios (HRs) of all-cause mortality and the life expectancy by levels of the lifestyle scores were estimated. Results Of 46,120 cancer survivors registered from 2010 to 2017, during an average follow-up of 4.3 years (200,285 person-years), 15,209 deaths were recorded. Adjusted HRs for mortality in cancer survivors with lifestyle score of 0-2, versus 5, were 2.59 (95% confidence interval (CI): 2.03-3.30) in women, 1.91 (95%CI 1.77-2.05) in men, 2.28 (95%CI 2.03-2.55) in those aged <65 years, and 1.90 (95%CI 1.75, 2.05) in those aged [greater than or equai to] 65 years. Life expectancy at age 55 for those with a score of 0-2 and 5 was 53.4 and 57.1 months, respectively. We also found that cancer survivors with healthy lifestyle scores of 5 showed 59.9 months of life expectancy on average, which was longer than those with a score of 0-2. Conclusion Adopting a healthy lifestyle was associated with a substantially lower risk of all-cause mortality and longer life expectancy in cancer survivors. Our findings should be useful for health education and health promotion in primary care and clinical practice. Keywords: Healthy lifestyle, Cancer survivor, Mortality, Life expectancy</description><subject>Age groups</subject><subject>Alcohol use</subject><subject>Behavior</subject><subject>Body mass index</subject><subject>Cancer</subject><subject>Cancer survivor</subject><subject>Cancer survivors</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>China</subject><subject>Chinese medicine</subject><subject>Cohort analysis</subject><subject>Confidence intervals</subject><subject>Health aspects</subject><subject>Health behavior</subject><subject>Health care</subject><subject>Health promotion</subject><subject>Healthy lifestyle</subject><subject>Life expectancy</subject><subject>Life span</subject><subject>Life style</subject><subject>Lifestyles</subject><subject>Medical records</subject><subject>Mortality</subject><subject>Municipal finance</subject><subject>Physical activity</subject><subject>Radiation therapy</subject><subject>Risk factors</subject><subject>Sleep</subject><subject>Smoking</subject><subject>Statistical analysis</subject><subject>Survival</subject><issn>1741-7015</issn><issn>1741-7015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkt9qFDEUxgdRbK2-gFcBQbyZmj8zyYwXwlKqFgre6HU4kzmzmyU7WZPMtvMQvnOzu0W7IiEk5PzOF_LlK4q3jF4y1siPkfGWyZJyliflVcmfFedMVaxUlNXPn-zPilcxrinltVLVy-JMVJy3Usrz4vciRm8sJOtH4geyQnBpNRNnB4xpdkii8QHJnU0rAs6VBqaIZONDAmfTTGDsDzDB-y2aBKOZPxEgJtfKO9sj2QYf9xW7Q2L8KjeSmKZ-3t9mMo6BxCns7M6H-Lp4MYCL-OZxvSh-frn-cfWtvP3-9eZqcVuaWrFUdiiga3glJKcoOykAetp3RrTYt7TLZjRDR2tKWS-GppIDUqMqoFBLpowy4qK4Oer2HtZ6G-wGwqw9WH048GGpISRrHOouO6sGQxWFpqpBgGKVYQJbLnthgGetz0et7dRtsDc4pgDuRPS0MtqVXvqdbrhkrWiywIdHgeB_Tdl1vbHRoHMwop-i5nXVsrZtWpnRd_-gaz-FMVuVqZo3IgeC_6WWkB9gx8Hne81eVC-k4kLI7EOmLv9D5dHjxho_4mDz-UnD-ycNx6BE76Z9dOIpyI-gyV8fAw5_zGBU75Orj8nVObn6kFzNxQNgseBD</recordid><startdate>20210707</startdate><enddate>20210707</enddate><creator>Sun, Ce</creator><creator>Li, Ke</creator><creator>Xu, Huan</creator><creator>Wang, Xiangjun</creator><creator>Qin, Pengzhe</creator><creator>Wang, Suixiang</creator><creator>Liang, Boheng</creator><creator>Xu, Lin</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20210707</creationdate><title>Association of healthy lifestyle score with all-cause mortality and life expectancy: a city-wide prospective cohort study of cancer survivors</title><author>Sun, Ce ; Li, Ke ; Xu, Huan ; Wang, Xiangjun ; Qin, Pengzhe ; Wang, Suixiang ; Liang, Boheng ; Xu, Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-be3ab8243620e6b63aad0dbc39ed90b0208fb05001d3f846fe0c74a0a5617c7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age groups</topic><topic>Alcohol use</topic><topic>Behavior</topic><topic>Body mass index</topic><topic>Cancer</topic><topic>Cancer survivor</topic><topic>Cancer survivors</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>China</topic><topic>Chinese medicine</topic><topic>Cohort analysis</topic><topic>Confidence intervals</topic><topic>Health aspects</topic><topic>Health behavior</topic><topic>Health care</topic><topic>Health promotion</topic><topic>Healthy lifestyle</topic><topic>Life expectancy</topic><topic>Life span</topic><topic>Life style</topic><topic>Lifestyles</topic><topic>Medical records</topic><topic>Mortality</topic><topic>Municipal finance</topic><topic>Physical activity</topic><topic>Radiation therapy</topic><topic>Risk factors</topic><topic>Sleep</topic><topic>Smoking</topic><topic>Statistical analysis</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Ce</creatorcontrib><creatorcontrib>Li, Ke</creatorcontrib><creatorcontrib>Xu, Huan</creatorcontrib><creatorcontrib>Wang, Xiangjun</creatorcontrib><creatorcontrib>Qin, Pengzhe</creatorcontrib><creatorcontrib>Wang, Suixiang</creatorcontrib><creatorcontrib>Liang, Boheng</creatorcontrib><creatorcontrib>Xu, Lin</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>BMC medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Ce</au><au>Li, Ke</au><au>Xu, Huan</au><au>Wang, Xiangjun</au><au>Qin, Pengzhe</au><au>Wang, Suixiang</au><au>Liang, Boheng</au><au>Xu, Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of healthy lifestyle score with all-cause mortality and life expectancy: a city-wide prospective cohort study of cancer survivors</atitle><jtitle>BMC medicine</jtitle><date>2021-07-07</date><risdate>2021</risdate><volume>19</volume><issue>1</issue><spage>1</spage><epage>158</epage><pages>1-158</pages><artnum>158</artnum><issn>1741-7015</issn><eissn>1741-7015</eissn><abstract>Background Adherence to a healthy lifestyle could reduce the cancer mortality in the western population. We conducted a city-wide prospective study in China investigating the association of a healthy lifestyle score with all-cause mortality and the life expectancy in cancer survivors. Methods This prospective cohort study included 46,120 surviving patients who were firstly diagnosed with cancer in Guangzhou. Five low-risk lifestyle factors including never smoking, never alcohol use, regular physical activity ([greater than or equai to] 2 h/week), sufficient sleep ([greater than or equai to] 6 h/day), and normal or high BMI ([greater than or equai to] 18.5 kg/m.sup.2) were assessed and a lifestyle score (0-5, a higher score indicates healthier lifestyle) was generated. Hazard ratios (HRs) of all-cause mortality and the life expectancy by levels of the lifestyle scores were estimated. Results Of 46,120 cancer survivors registered from 2010 to 2017, during an average follow-up of 4.3 years (200,285 person-years), 15,209 deaths were recorded. Adjusted HRs for mortality in cancer survivors with lifestyle score of 0-2, versus 5, were 2.59 (95% confidence interval (CI): 2.03-3.30) in women, 1.91 (95%CI 1.77-2.05) in men, 2.28 (95%CI 2.03-2.55) in those aged <65 years, and 1.90 (95%CI 1.75, 2.05) in those aged [greater than or equai to] 65 years. Life expectancy at age 55 for those with a score of 0-2 and 5 was 53.4 and 57.1 months, respectively. We also found that cancer survivors with healthy lifestyle scores of 5 showed 59.9 months of life expectancy on average, which was longer than those with a score of 0-2. Conclusion Adopting a healthy lifestyle was associated with a substantially lower risk of all-cause mortality and longer life expectancy in cancer survivors. Our findings should be useful for health education and health promotion in primary care and clinical practice. Keywords: Healthy lifestyle, Cancer survivor, Mortality, Life expectancy</abstract><cop>London</cop><pub>BioMed Central Ltd</pub><pmid>34229666</pmid><doi>10.1186/s12916-021-02024-2</doi><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1741-7015 |
ispartof | BMC medicine, 2021-07, Vol.19 (1), p.1-158, Article 158 |
issn | 1741-7015 1741-7015 |
language | eng |
recordid | cdi_doaj_primary_oai_doaj_org_article_b2027fc070a845a3a714c13e926d3ca2 |
source | Publicly Available Content Database; PubMed Central |
subjects | Age groups Alcohol use Behavior Body mass index Cancer Cancer survivor Cancer survivors Cancer therapies Chemotherapy China Chinese medicine Cohort analysis Confidence intervals Health aspects Health behavior Health care Health promotion Healthy lifestyle Life expectancy Life span Life style Lifestyles Medical records Mortality Municipal finance Physical activity Radiation therapy Risk factors Sleep Smoking Statistical analysis Survival |
title | Association of healthy lifestyle score with all-cause mortality and life expectancy: a city-wide prospective cohort study of cancer survivors |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T09%3A25%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20healthy%20lifestyle%20score%20with%20all-cause%20mortality%20and%20life%20expectancy:%20a%20city-wide%20prospective%20cohort%20study%20of%20cancer%20survivors&rft.jtitle=BMC%20medicine&rft.au=Sun,%20Ce&rft.date=2021-07-07&rft.volume=19&rft.issue=1&rft.spage=1&rft.epage=158&rft.pages=1-158&rft.artnum=158&rft.issn=1741-7015&rft.eissn=1741-7015&rft_id=info:doi/10.1186/s12916-021-02024-2&rft_dat=%3Cgale_doaj_%3EA672336561%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c571t-be3ab8243620e6b63aad0dbc39ed90b0208fb05001d3f846fe0c74a0a5617c7c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2552832912&rft_id=info:pmid/34229666&rft_galeid=A672336561&rfr_iscdi=true |