Diagnosis and mortality prediction of sepsis via lysophosphatidylcholine 16:0 measured by MALDI-TOF MS

Sepsis remains a critical problem with high mortality worldwide, but there is still a lack of reliable biomarkers. We aimed to evaluate the serum lysophosphatidylcholine (LPC) 16:0 as a biomarker of sepsis using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2020-08, Vol.10 (1), p.13833-13833, Article 13833
Main Authors: Lee, Eun Hye, Shin, Mi Hwa, Park, Jong-Min, Lee, Sang-Guk, Ku, Nam Su, Kim, Young Sam, Park, Moo Suk, Pyun, Jae-Chul, Chung, Kyung Soo
Format: Article
Language:English
Subjects:
631/45/287/1194
692/53/2421
692/53/2423
692/699/255/1318
Aged
Biomarkers
Biomarkers - blood
Diagnosis
Female
Humanities and Social Sciences
Humans
Inflammation
Intensive Care Units
Ionization
Ions
Lactic acid
Lysophosphatidylcholine
Lysophosphatidylcholines - blood
Male
Mass spectrometry
Mass spectroscopy
Mechanical ventilation
Mortality
multidisciplinary
Predictive Value of Tests
Science
Science (multidisciplinary)
Sepsis
Sepsis - diagnosis
Sepsis - mortality
Septic shock
Shock, Septic - diagnosis
Shock, Septic - mortality
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
Survival Rate
Systemic inflammatory response syndrome
Systemic Inflammatory Response Syndrome - diagnosis
Systemic Inflammatory Response Syndrome - mortality
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sepsis remains a critical problem with high mortality worldwide, but there is still a lack of reliable biomarkers. We aimed to evaluate the serum lysophosphatidylcholine (LPC) 16:0 as a biomarker of sepsis using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Patients admitted to intensive care unit at Severance Hospital from March 2017 through June 2018 were prospectively enrolled. The inclusion criteria were the fulfillment of at least two criteria of systemic inflammatory response syndrome (SIRS) or the presence of sepsis. Of the 127 patients, 14 had non-infectious SIRS, 41 had sepsis, and 72 had septic shock. The mean serum LPC 16:0 concentration (µmol/L) in non-infectious SIRS was significantly higher than in patients with sepsis and septic shock (101.1 vs. 48.92, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-70799-0