Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage

The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation. Its implication on long-term memory (LTM) formation led to postulate the behavioral tagging mechanism. Here we show that a maintenance tagging proc...

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Bibliographic Details
Published in:Journal of neural transplantation & plasticity 2015-01, Vol.2015 (2015), p.1018-1026-088
Main Authors: Medina, Jorge H., Viola, Haydee, Katche, Cynthia, Tomaiuolo, Micol
Format: Article
Language:English
Subjects:
Animals
Avoidance Learning
Cytoskeletal Proteins - biosynthesis
Environment
Experiments
Hippocampus (Brain)
Hippocampus - physiology
Hypotheses
Laboratory animals
Long-term memory
Male
Memory, Long-Term - physiology
Motor Activity
Nerve Tissue Proteins - biosynthesis
Neural transmission
Rats
Rats, Wistar
Receptors, Dopamine D1 - physiology
Receptors, Dopamine D5 - physiology
Recognition, Psychology
Surgery
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Summary:The synaptic tagging and capture (STC) hypothesis provides a compelling explanation for synaptic specificity and facilitation of long-term potentiation. Its implication on long-term memory (LTM) formation led to postulate the behavioral tagging mechanism. Here we show that a maintenance tagging process may operate in the hippocampus late after acquisition for the persistence of long-lasting memory storage. The proposed maintenance tagging has several characteristics: (1) the tag is transient and time-dependent; (2) it sets in a late critical time window after an aversive training which induces a short-lasting LTM; (3) exposing rats to a novel environment specifically within this tag time window enables the consolidation to a long-lasting LTM; (4) a familiar environment exploration was not effective; (5) the effect of novelty on the promotion of memory persistence requires dopamine D1/D5 receptors and Arc expression in the dorsal hippocampus. The present results can be explained by a broader version of the behavioral tagging hypothesis and highlight the idea that the durability of a memory trace depends either on late tag mechanisms induced by a training session or on events experienced close in time to this tag.
ISSN:0792-8483
2090-5904
1687-5443
DOI:10.1155/2015/603672