Incidence and features of thrombosis in children with inherited antithrombin deficiency

Pediatric thromboembolism (≤18 years) is very rare (0.07-0.14/10,000/year) but may be more prevalent in children with severe thrombophilia (protein C, protein S or antithrombin deficiency). The aim of this study was to define the prevalence and clinical characteristics of pediatric thrombosis in sub...

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Bibliographic Details
Published in:Haematologica (Roma) 2019-12, Vol.104 (12), p.2512-2518
Main Authors: de la Morena-Barrio, Belén, Orlando, Christelle, de la Morena-Barrio, María Eugenia, Vicente, Vicente, Jochmans, Kristin, Corral, Javier
Format: Article
Language:English
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Summary:Pediatric thromboembolism (≤18 years) is very rare (0.07-0.14/10,000/year) but may be more prevalent in children with severe thrombophilia (protein C, protein S or antithrombin deficiency). The aim of this study was to define the prevalence and clinical characteristics of pediatric thrombosis in subjects with inherited antithrombin deficiency. Our observational retrospective multicentric study from two countries recruited 968 patients of any age from 441 unrelated families with genetically, biochemically and functionally characterized antithrombin deficiency. Seventy-three subjects (7.5%) developed thrombosis before 19 years of age. Two high-risk periods for thrombosis were identified: adolescence (12-18 years, n=49) with thrombus localization (lower limb deep venous thrombosis or pulmonary embolism) and triggering factors common to adults (oral contraceptives, surgery or pregnancy); and the neonatal period (
ISSN:0390-6078
1592-8721
DOI:10.3324/haematol.2018.210666