An Update of the Promise of Glycine Supplementation for Enhancing Physical Performance and Recovery

Glycine, the simple amino acid, is a key component of muscle metabolism with proven cytoprotective effects and hypothetical benefits as a therapeutic nutrient. Cell, in vitro, and animal studies suggest that glycine enhances protection against muscle wasting by activating anabolic pathways and inhib...

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Bibliographic Details
Published in:Sports (Basel) 2024-09, Vol.12 (10), p.265
Main Authors: Ramos-Jiménez, Arnulfo, Hernández-Torres, Rosa Patricia, Hernández-Ontiveros, David Alfredo, Ortiz-Ortiz, Melinna, López-Fregoso, Reymond Josué, Martínez-Sanz, José Miguel, Rodríguez-Uribe, Genaro, Hernández-Lepe, Marco Antonio
Format: Article
Language:English
Subjects:
Amino acids
Athletes
athletic performance
Body mass
Carbon
Clinical trials
Collagen
Connective tissue
Cytotoxicity
Diabetes
Dietary supplements
Dosage and administration
Drug therapy
Extracellular matrix
Functional foods & nutraceuticals
Gene expression
Glycine
Homeostasis
human metabolism
Inflammation
Kidneys
Kinases
Literature reviews
Metabolism
Muscle fatigue
Muscle function
Muscle strength
Musculoskeletal system
Obesity
oxidative stress
physical exercise
Physiological aspects
Physiology
Plasma
Protein synthesis
Proteins
Proteolysis
Review
Schizophrenia
Sleep
sports medicine
Testing
Citations: Items that this one cites
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Summary:Glycine, the simple amino acid, is a key component of muscle metabolism with proven cytoprotective effects and hypothetical benefits as a therapeutic nutrient. Cell, in vitro, and animal studies suggest that glycine enhances protection against muscle wasting by activating anabolic pathways and inhibiting proteolytic gene expression. Some evidence indicates that glycine supplementation may enhance peak power output, reduce lactic acid accumulation during high-intensity exercise, and improve sleep quality and recovery. This literature review critically explores glycine's potential as an ergogenic aid and its relevance to muscle regeneration, muscle strength, endurance exercise performance, and sleep quality. It also underscores key areas for future research. It is concluded that more randomized controlled clinical trials in humans are needed to confirm glycine's potential as a dietary supplement to support muscle function, recovery, and overall athletic performance as an ergogenic aid and to establish nutritional recommendations for athletic performance. Also, it is essential to consider that high doses (>500 mg/kg of body mass) could induce cytotoxic effects and contribute to acute glutamate toxicity.
ISSN:2075-4663
2075-4663
DOI:10.3390/sports12100265