Synthesis of 2-azetidinones substituted quinoline derivative

Acetanilide is converted into 2-chloro-3-formyl quinoline by reacting with DMF-POCl3 at 80-90?C and then condensed with aromatic primary amines to give Schiff bases (3a-3c). These Schiff bases are then reacted with acid chlorides in the presence of base in toluene to give 1, 3, 4-substituted 2-azeti...

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Bibliographic Details
Published in:Journal of the Serbian Chemical Society 2013, Vol.78 (5), p.621-625
Main Authors: Mashelkar, Uday, Jha, Mukesh, Mashelkar, Beena
Format: Article
Language:English
Subjects:
2-azetidinone
2-chloro-3-formyl quinoline
acetanilide
acid chloride
aromatic amine
tri-n-butylamine
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Summary:Acetanilide is converted into 2-chloro-3-formyl quinoline by reacting with DMF-POCl3 at 80-90?C and then condensed with aromatic primary amines to give Schiff bases (3a-3c). These Schiff bases are then reacted with acid chlorides in the presence of base in toluene to give 1, 3, 4-substituted 2-azetidinones. nema
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC120617081M