Citrus Flavanone Narirutin, In Vitro and In Silico Mechanistic Antidiabetic Potential

Citrus fruits and juices have been studied extensively for their potential involvement in the prevention of various diseases. Flavanones, the characteristic polyphenols of citrus species, are the primarily compounds responsible for these studied health benefits. Using in silico and in vitro methods,...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutics 2021-10, Vol.13 (11), p.1818
Main Authors: Qurtam, Ashraf Ahmed, Mechchate, Hamza, Es-safi, Imane, Al-zharani, Mohammed, Nasr, Fahd A., Noman, Omar M., Aleissa, Mohammed, Imtara, Hamada, Aleissa, Abdulmalik M., Bouhrim, Mohamed, Alqahtani, Ali S.
Format: Article
Language:English
Subjects:
Amino acids
Citrus fruits
Diabetes
enzyme
Enzymes
Fatty acids
Flavonoids
Gene expression
Glucose
Hydrogen bonds
Hypoglycemia
Insulin resistance
isonaringin
Kinases
Ligands
mechanism of action
Metabolism
Metabolites
molecular docking
naringenin rutinoside
narirutin
Proteins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Citrus fruits and juices have been studied extensively for their potential involvement in the prevention of various diseases. Flavanones, the characteristic polyphenols of citrus species, are the primarily compounds responsible for these studied health benefits. Using in silico and in vitro methods, we are exploring the possible antidiabetic action of narirutin, a flavanone family member. The goal of the in silico research was to anticipate how narirutin would interact with eight distinct receptors implicated in diabetes control and complications, namely, dipeptidyl-peptidase 4 (DPP4), protein tyrosine phosphatase 1B (PTP1B), free fatty acid receptor 1 (FFAR1), aldose reductase (AldR), glycogen phosphorylase (GP), alpha-amylase (AAM), peroxisome proliferator-activated receptor gamma (PPAR-γ), alpha-glucosidase (AGL), while the in vitro study looked into narirutin’s possible inhibitory impact on alpha-amylase and alpha-glucosidase. The results indicate that the studied citrus flavanone interacted remarkably with most of the receptors and had an excellent inhibitory activity during the in vitro tests suggesting its potent role among the different constituent of the citrus compounds in the management of diabetes and also its complications.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13111818