Citrus Flavanone Narirutin, In Vitro and In Silico Mechanistic Antidiabetic Potential

• Published in: Pharmaceutics 2021-10, Vol.13 (11), p.1818
• Main Authors: Qurtam, Ashraf Ahmed, Mechchate, Hamza, Es-safi, Imane, Al-zharani, Mohammed, Nasr, Fahd A., Noman, Omar M., Aleissa, Mohammed, Imtara, Hamada, Aleissa, Abdulmalik M., Bouhrim, Mohamed, Alqahtani, Ali S.
• Format: Article
• Language: English
• Subjects: Amino acids; Citrus fruits; Diabetes; enzyme; Enzymes; Fatty acids; Flavonoids; Gene expression; Glucose; Hydrogen bonds; Hypoglycemia; Insulin resistance; isonaringin; Kinases; Ligands; mechanism of action; Metabolism; Metabolites; molecular docking; naringenin rutinoside; narirutin; Proteins
• ISSN: 1999-4923; 1999-4923
• DOI: 10.3390/pharmaceutics13111818

Citrus fruits and juices have been studied extensively for their potential involvement in the prevention of various diseases. Flavanones, the characteristic polyphenols of citrus species, are the primarily compounds responsible for these studied health benefits. Using in silico and in vitro methods, we are exploring the possible antidiabetic action of narirutin, a flavanone family member. The goal of the in silico research was to anticipate how narirutin would interact with eight distinct receptors implicated in diabetes control and complications, namely, dipeptidyl-peptidase 4 (DPP4), protein tyrosine phosphatase 1B (PTP1B), free fatty acid receptor 1 (FFAR1), aldose reductase (AldR), glycogen phosphorylase (GP), alpha-amylase (AAM), peroxisome proliferator-activated receptor gamma (PPAR-γ), alpha-glucosidase (AGL), while the in vitro study looked into narirutin’s possible inhibitory impact on alpha-amylase and alpha-glucosidase. The results indicate that the studied citrus flavanone interacted remarkably with most of the receptors and had an excellent inhibitory activity during the in vitro tests suggesting its potent role among the different constituent of the citrus compounds in the management of diabetes and also its complications.