Angiographic characteristics of vasculopathy in patients with idiopathic inflammatory myopathies and systemic sclerosis

To describe the peripheral angiographic features of vasculopathy in idiopathic inflammatory myopathies (IIM) and systemic sclerosis (SSc) in comparison to polyarteritis nodosa (PAN). Angiograms of 47 extremities (24 upper and 23 lower) of 11 patients with IIM (n = 5) and SSc (n = 6), and 12 patients...

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Bibliographic Details
Published in:Scientific reports 2022-05, Vol.12 (1), p.9051-9051, Article 9051
Main Authors: Yeo, Jina, Park, Eun-Ah, Lee, Eun Bong, Park, Jin Kyun
Format: Article
Language:English
Subjects:
692/4023/1670/122
692/4023/1670/595
692/700/1421/1770
Amputation
Aneurysm
Aneurysms
Angiography
Arteries
Constriction, Pathologic
Extremities
Humanities and Social Sciences
Humans
Inflammation
Ischemia
multidisciplinary
Myositis - diagnostic imaging
Occlusion
Polyarteritis Nodosa
Prospective Studies
Retrospective Studies
Science
Science (multidisciplinary)
Scleroderma
Scleroderma, Systemic - diagnostic imaging
Stenosis
Systemic sclerosis
Vascular diseases
Vascularization
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Summary:To describe the peripheral angiographic features of vasculopathy in idiopathic inflammatory myopathies (IIM) and systemic sclerosis (SSc) in comparison to polyarteritis nodosa (PAN). Angiograms of 47 extremities (24 upper and 23 lower) of 11 patients with IIM (n = 5) and SSc (n = 6), and 12 patients with PAN who presented with critical limb ischemia were retrospectively analyzed with regards to the presence of stenosis, occlusion, aneurysms and delayed distal flow, and degree of neovascularization. Diffuse narrowing was more frequent (66.1 vs. 38.0%, p  = 0.001), whereas multifocal stenosis (6.5% vs. 26.8%, p  = 0.002), abrupt occlusion (11.3% vs. 29.6%, p  = 0.010) and aneurysm formation (1.6% vs. 11.3%, p  = 0.037) were less frequent in IIM/SSc than PAN. In distal arteries, tapered occlusion (95.5% vs. 76.0%, p  = ns) and delayed flow (77.3% vs. 48.0%, p  = 0.039) were more common in IIM/SSc than PAN. After 1 year, auto- or surgical amputation tended to be more frequent in IIM/SSc than PAN (36.4% vs. 16.7%, p  = ns). In conclusion, diffuse narrowing, tapered occlusion and delayed distal flow on conventional angiograms tend to be more frequent in IIM/SSc than PAN. Further studies are needed to verify these findings in a larger prospective cohort.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-12991-y