Correlation between Angiotensin Serum Levels and Very-Low-Frequency Spectral Power of Heart Rate Variability during Hemodialysis

Cardiovascular regulatory mechanisms that fail to compensate for ultrafiltration and cause hypovolemia during hemodialysis (HD) are not completely understood. This includes the interaction between the autonomic nervous system and the biochemistry that regulates blood pressure and modulates cardiac a...

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Published in:Life (Basel, Switzerland) Switzerland), 2022-07, Vol.12 (7), p.1020
Main Authors: del Valle-Mondragón, Leonardo, Becerra-Luna, Brayans, Cartas-Rosado, Raúl, Infante, Oscar, Pérez-Grovas, Héctor, Lima-Zapata, Larissa I., Lerma, Claudia, Rodríguez-Chagolla, José, Martínez-Memije, Raúl
Format: Article
Language:English
Subjects:
Angiotensin
angiotensin 1–7
Angiotensin II
Antioxidants
autonomic cardiac modulation
Autonomic nervous system
Biomarkers
Blood pressure
Cardiovascular system
Correlation
end-stage renal disease
Heart rate
Hemodialysis
Hemodynamics
Hemoglobin
Hypertension
Hypotension
Hypovolemia
Nervous system
Nitric oxide
Regulatory mechanisms (biology)
Serum levels
Ultrafiltration
Very Low Frequencies
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Summary:Cardiovascular regulatory mechanisms that fail to compensate for ultrafiltration and cause hypovolemia during hemodialysis (HD) are not completely understood. This includes the interaction between the autonomic nervous system and the biochemistry that regulates blood pressure and modulates cardiac activity and vascular tone in response to hypovolemia in patients treated with HD. The objective was to evaluate the association of spectral indices of heart rate variability (HRV) with serum levels of angiotensin II, angiotensin 1–7, nitric oxide and total antioxidant capacity during HD. Electrocardiographic records were obtained from 20 patients during HD (3 h), from which HRV data and spectral power data in the very-low-frequency (VLF), low-frequency (LF) and high-frequency (HF) bands were generated. Three blood samples per patient were collected during HD (0.0, 1.5, 3.0 h) to determine the levels of biomarkers involved in the pressor response during HD. Angiotensin II had a positive correlation with VLF (r = 0.390) and with LF/HF (r = 0.359) and a negative correlation with LF (r = −0.262) and HF (r = −0.383). There were no significant correlations between HRV and the other biomarkers. These results suggest that during HD, VLF could reflect the serum levels of angiotensin II, which may be associated with the autonomic response to HD.
ISSN:2075-1729
2075-1729
DOI:10.3390/life12071020