Specific motor cortex hypoexcitability and hypoactivation in COPD patients with peripheral muscle weakness

Peripheral muscle weakness can be caused by both peripheral muscle and neural alterations. Although peripheral alterations cannot totally explain peripheral muscle weakness in COPD, the existence of an activation deficit remains controversial. The heterogeneity of muscle weakness (between 32 and 57%...

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Bibliographic Details
Published in:BMC pulmonary medicine 2020-01, Vol.20 (1), p.1-1, Article 1
Main Authors: Alexandre, Francois, Héraud, Nelly, Tremey, Emilie, Oliver, Nicolas, Bourgouin, Dominique, Varray, Alain
Format: Article
Language:English
Subjects:
Brain
Chronic obstructive lung disease
Chronic obstructive pulmonary disease
Cognitive science
Complications and side effects
Consortia
Cortex (motor)
Corticospinal excitability
Development and progression
Diseases
Excitability
Health aspects
Human health and pathology
Hypotheses
Life Sciences
Lung diseases
Motor cortex
Motor evoked potentials
Muscle weakness
Neuroscience
Peripheral muscle weakness
Peripheral nerves
Physiological aspects
Pulmonology
Pulmonology and respiratory tract
Pyramidal tracts
Quadriceps muscle
Studies
Therapeutic applications
Tissues and Organs
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Summary:Peripheral muscle weakness can be caused by both peripheral muscle and neural alterations. Although peripheral alterations cannot totally explain peripheral muscle weakness in COPD, the existence of an activation deficit remains controversial. The heterogeneity of muscle weakness (between 32 and 57% of COPD patients) is generally not controlled in studies and could explain this discrepancy. This study aimed to specifically compare voluntary and stimulated activation levels in COPD patients with and without muscle weakness. Twenty-two patients with quadriceps weakness (COPD ), 18 patients with preserved quadriceps strength (COPD ) and 20 controls were recruited. Voluntary activation was measured through peripheral nerve (VA ) and transcranial magnetic (VA ) stimulation. Corticospinal and spinal excitability (MEP/Mmax and Hmax/Mmax) and corticospinal inhibition (silent period duration) were assessed during maximal voluntary quadriceps contractions. COPD exhibited lower VA and lower MEP/Mmax compared with COPD (p 
ISSN:1471-2466
1471-2466
DOI:10.1186/s12890-019-1042-0