Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalysed Suzuki–Miyaura Coupling of 4-Pyrimidyl Tosylates in Water

Abstract The Suzuki–Miyaura coupling reaction of 4-pyrimidyl tosylates was investigated with aryl, heteroaryl and alkyl boronic acids. The reaction provided 4-substituted pyrimidines in good-to-excellent yields after one-hour microwave irradiation in water at 100 °C. The method constitutes a fast op...

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Bibliographic Details
Published in:SynOpen (2017) 2017-03, Vol.1 (1), p.0024-0028
Main Authors: Rodríguez-Aguilar, José, Ordóñez, Beatriz, Vidal, Matías, Rezende, Marcos Caroli, Domínguez, Moisés
Format: Article
Language:English
Subjects:
cross-coupling
letter
microwave-accelerated synthesis
pyrimidines
suzuki–miyaura coupling
tosylates
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Summary:Abstract The Suzuki–Miyaura coupling reaction of 4-pyrimidyl tosylates was investigated with aryl, heteroaryl and alkyl boronic acids. The reaction provided 4-substituted pyrimidines in good-to-excellent yields after one-hour microwave irradiation in water at 100 °C. The method constitutes a fast option for the synthesis of these heterocyclic systems.
ISSN:2509-9396
2509-9396
DOI:10.1055/s-0036-1588810