Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study

Acne is a skin condition of the pilosebaceous unit that affects mainly the face, chest and trunk. Approximately 50% of subjects with facial acne also have acne of the trunk. This study investigated the clinical benefit of a cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydr...

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Published in:Clinical, cosmetic and investigational dermatology cosmetic and investigational dermatology, 2023-01, Vol.16, p.119-123
Main Authors: Towersey, Loan, Correia, Priscila, Fajgenbaum Feiges, Mariana, Euzébio Gonçalves Junior, José, Sant'Anna, Beatriz, Kerob, Delphine, Le Floc'h, Caroline
Format: Article
Language:English
Subjects:
Acids
Acne
Analysis
Care and treatment
deep cleansing gel
Females
lha
lipo hydroxy acids
Pathogenesis
Phenols
Rapid Communication
salicylic acid
Skin
truncal acne
Zinc gluconate
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container_title Clinical, cosmetic and investigational dermatology
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creator Towersey, Loan
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Fajgenbaum Feiges, Mariana
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description Acne is a skin condition of the pilosebaceous unit that affects mainly the face, chest and trunk. Approximately 50% of subjects with facial acne also have acne of the trunk. This study investigated the clinical benefit of a cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydroxy acid 0.05% in truncal acne after 84 days of daily use. A single center, open label, non-randomized study with 51 subjects with mild to moderate truncal acne was conducted. Thirty-five (35) subjects completed the study; mean age was 23 years. Inflammatory and non-inflammatory lesions, Transepidermal water loss (TEWL) and local tolerance were assessed at baseline, Day 42 and Day 84 and total lesion count was calculated. The total lesion count was significantly reduced (p
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Approximately 50% of subjects with facial acne also have acne of the trunk. This study investigated the clinical benefit of a cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydroxy acid 0.05% in truncal acne after 84 days of daily use. A single center, open label, non-randomized study with 51 subjects with mild to moderate truncal acne was conducted. Thirty-five (35) subjects completed the study; mean age was 23 years. Inflammatory and non-inflammatory lesions, Transepidermal water loss (TEWL) and local tolerance were assessed at baseline, Day 42 and Day 84 and total lesion count was calculated. The total lesion count was significantly reduced (p&lt;0.05) after 42 days (-21.5%) and 84 days (-56.3%). Non-inflammatory lesions were significantly decreased after 84 days (-64.0%) only, while inflammatory lesions were decreased at Day 42 (-29.2%), and Day 84 (-48.2%). A statistically significant skin barrier improvement was observed at Day 84 (-21.26%). No adverse events or relevant local intolerance were reported. The use of the cleansing gel studied was effective in improving mild to moderate truncal acne and contributed to the skin barrier improvement. The product was well tolerated. NCT05584150.</description><identifier>ISSN: 1178-7015</identifier><identifier>EISSN: 1178-7015</identifier><identifier>DOI: 10.2147/CCID.S394123</identifier><identifier>PMID: 36698447</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Acids ; Acne ; Analysis ; Care and treatment ; deep cleansing gel ; Females ; lha ; lipo hydroxy acids ; Pathogenesis ; Phenols ; Rapid Communication ; salicylic acid ; Skin ; truncal acne ; Zinc gluconate</subject><ispartof>Clinical, cosmetic and investigational dermatology, 2023-01, Vol.16, p.119-123</ispartof><rights>2023 Towersey et al.</rights><rights>COPYRIGHT 2023 Dove Medical Press Limited</rights><rights>2023. 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Approximately 50% of subjects with facial acne also have acne of the trunk. This study investigated the clinical benefit of a cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydroxy acid 0.05% in truncal acne after 84 days of daily use. A single center, open label, non-randomized study with 51 subjects with mild to moderate truncal acne was conducted. Thirty-five (35) subjects completed the study; mean age was 23 years. Inflammatory and non-inflammatory lesions, Transepidermal water loss (TEWL) and local tolerance were assessed at baseline, Day 42 and Day 84 and total lesion count was calculated. The total lesion count was significantly reduced (p&lt;0.05) after 42 days (-21.5%) and 84 days (-56.3%). Non-inflammatory lesions were significantly decreased after 84 days (-64.0%) only, while inflammatory lesions were decreased at Day 42 (-29.2%), and Day 84 (-48.2%). A statistically significant skin barrier improvement was observed at Day 84 (-21.26%). 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source Taylor & Francis; Publicly Available Content Database; PubMed Central
subjects Acids
Acne
Analysis
Care and treatment
deep cleansing gel
Females
lha
lipo hydroxy acids
Pathogenesis
Phenols
Rapid Communication
salicylic acid
Skin
truncal acne
Zinc gluconate
title Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study
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