In-situ TiO2-x decoration of titanium carbide MXene for photo/sono-responsive antitumor theranostics

Sonodynamic therapy (SDT) has emerged as a noninvasive therapeutic modality that involves sonosensitizers and low-intensity ultrasound. However, owing to the rapid recombination of charge carriers, most of the sonosensitizers triggered poor reactive oxygen species (ROS) generation, resulting in unsa...

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Bibliographic Details
Published in:Journal of nanobiotechnology 2022-01, Vol.20 (1), p.1-14, Article 53
Main Authors: Zhang, Dong-Yang, Liu, Hengke, Younis, Muhammad Rizwan, Lei, Shan, Chen, Yunzhi, Huang, Peng, Lin, Jing
Format: Article
Language:English
Subjects:
Biocompatibility
Biodistribution
Blood flow
Cancer
Carbides
Care and treatment
Current carriers
Diagnosis
Fever
Health aspects
Hyperthermia
Hypoxia
Infrared imaging
Laboratory animals
Lasers
MXenes
Nanomaterials
Nanoparticles
Near infrared radiation
Oxygen deficient titanium dioxide
Oxygenation
Patient outcomes
Photoacoustic imaging
Photochemotherapy
Photothermal therapy
Polyethylene glycol
Precision medicine
Reactive oxygen species
Recombination
Risk factors
Sonodynamic therapy
Stainless steel
Titanium
Titanium carbide
Titanium dioxide
Titanium carbide
Toxicity
Tumors
Ultrasound
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Summary:Sonodynamic therapy (SDT) has emerged as a noninvasive therapeutic modality that involves sonosensitizers and low-intensity ultrasound. However, owing to the rapid recombination of charge carriers, most of the sonosensitizers triggered poor reactive oxygen species (ROS) generation, resulting in unsatisfactory sonodynamic therapeutic effects. Herein, a photo/sono-responsive nanoplatform was developed through the in-situ systhesis of TiO.sub.2-x on the surface of two-dimensional MXene (titanium carbide, Ti.sub.3C.sub.2) for photoacoustic/photothermal bimodal imaging-guided near-infrared II (NIR-II) photothermal enhanced SDT of tumor. Because of several oxygen vacancies and smaller size (~ 10 nm), the in-situ formed TiO.sub.2-x nanoparticles possessed narrow band gap (2.65 eV) and high surface area, and thus served as a charge trap to restrict charge recombination under ultrasound (US) activation, resulting in enhanced sonodynamic ROS generation. Moreover, Ti.sub.3C.sub.2 nanosheets induced extensive localized hyperthermia relieves tumor hypoxia by accelerating intratumoral blood flow and tumor oxygenation, and thus further strengthened the efficacy of SDT. Upon US/NIR-II laser dual-stimuli, Ti.sub.3C.sub.2@TiO.sub.2-x nanoplatform triggered substantial cellular killing in vitro and complete tumor eradication in vivo, without any tumor recurrence and systemic toxicity. Our work presents the promising design of photo/sono-responsive nanoplatform for cancer nanotheranostics.
ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-022-01253-8